2025-05-31_00000022|hard|8ZQC

Cryo-EM structure of Cas12X2 with crRNA and Target DNA; Electron microscopy 3.40Å
Protein #1 957 residues (97% resolved)

HHHHHHMKKWLRSYDFSLEVSEEDTLHLLECVKEYNELSKAYMDYMFKLKEDHKDDLDVCNLIERLQNGSGKELRALASCIFGGRKTSEDVFLRVKSYKKALVLIDSGEVKTYEDLSKSLGEKTGLRGTNSLFKEPKKEGKRKDRTGPLKEDQAKKINKMLAADLGIVSALNLCQKGLLPIPEFAKNVEKLNKNVLYGIISQAGSRMKSFLKCDDLTQQNHLNLKEILKSYRLEYNLDEFQEQEASYQQWLSRMKSLNSFALTHRFLQGWAKRWRKQFLAGKDPSWTLGEEATKICKEYQHLFVDNDFIYLFGKEDLLKLKVEERKQNAQFTLPDVIKSPIYPQLGNNGQGFGIEQVDNDIYLIIQSCFIDRPNIRAKIVPHKKTSVWSLEQENTKQTKKKNAQIDKNKIPYKLFLRRAADRYEKQIEISECRLQHRFCSGKANFHVVFSLKGEANDTLTKASTLFLTATQKPVSEWSKDNLPKQMRVAFVDIGLNPPLSMSIYDYNQEDNSGENLVYAGADQQVPFGSANFVREDQIGNVYNQNLKRRIEELNDKIFYASSCVSFYKNISSLEGATVELVGGRKVMCRQFDEEKVKDLYSVPVKALRELGLDHFFGLPEDLDQQNVEAATFYIENHIHHNKLTRKSFLSFRCKLWDYIHEKILPEFSVIRNGRHFQFNKQFCSEAYSWMFLIHSMIRLKKSLSYSHSEPLKKGEPATFVFKNLQNYFNNFSKNVLKTVAAKLRDYCTTHNVSLCVVEDLEKFRTSSLNSKDKNRLLSIWSHRNVVQRFEEVLTEVGITIVSNDARHSSQLDPVTMDWAYRDEQDKSKLWVKRDGEIFHINADISSTQVQAKRFFSRYADIVYMKTLLKKDDNGSLRKLVVSDNSTRIQSYLLRTINSKYAILEQDKLVPINQQEYNQIVGLKTSGVEEIYRHGESWVNLITHKTLQKEIGARTNVQ

HHHHHHMKKWLRSYDFSLEVSEEDTLHLLECVKEYNELSKAYMDYMFKLKEDHKDDLDVCNLIERLQNGSGKELRALASCIFGGRKTSEDVFLRVKSYKKALVLIDSGEVKTYEDLSKSLGEKTGLRGTNSLFKEPKKEGKRKDRTGPLKEDQAKKINKMLAADLGIVSALNLCQKGLLPIPEFAKNVEKLNKNVLYGIISQAGSRMKSFLKCDDLTQQNHLNLKEILKSYRLEYNLDEFQEQEASYQQWLSRMKSLNSFALTHRFLQGWAKRWRKQFLAGKDPSWTLGEEATKICKEYQHLFVDNDFIYLFGKEDLLKLKVEERKQNAQFTLPDVIKSPIYPQLGNNGQGFGIEQVDNDIYLIIQSCFIDRPNIRAKIVPHKKTSVWSLEQENTKQTKKKNAQIDKNKIPYKLFLRRAADRYEKQIEISECRLQHRFCSGKANFHVVFSLKGEANDTLTKASTLFLTATQKPVSEWSKDNLPKQMRVAFVDIGLNPPLSMSIYDYNQEDNSGENLVYAGADQQVPFGSANFVREDQIGNVYNQNLKRRIEELNDKIFYASSCVSFYKNISSLEGATVELVGGRKVMCRQFDEEKVKDLYSVPVKALRELGLDHFFGLPEDLDQQNVEAATFYIENHIHHNKLTRKSFLSFRCKLWDYIHEKILPEFSVIRNGRHFQFNKQFCSEAYSWMFLIHSMIRLKKSLSYSHSEPLKKGEPATFVFKNLQNYFNNFSKNVLKTVAAKLRDYCTTHNVSLCVVEDLEKFRTSSLNSKDKNRLLSIWSHRNVVQRFEEVLTEVGITIVSNDARHSSQLDPVTMDWAYRDEQDKSKLWVKRDGEIFHINADISSTQVQAKRFFSRYADIVYMKTLLKKDDNGSLRKLVVSDNSTRIQSYLLRTINSKYAILEQDKLVPINQQEYNQIVGLKTSGVEEIYRHGESWVNLITHKTLQKEIGARTNVQ
RNA #2 56 bases

GUGCUACAAGCGAAAAAGAUCGCUUGUGAUUUGCACUCCCCUACGUGCUGCUGAAG

GUGCUACAAGCGAAAAAGAUCGCUUGUGAUUUGCACUCCCCUACGUGCUGCUGAAG
DNA #3 42 bases

(DC)(DT)(DG)(DC)(DC)(DC)(DT)(DT)(DG)(DC)(DA)(DA)(DA)(DG)(DT)(DC)(DA)(DG)(DC)(DA)(DG)(DC)(DA)(DC)(DG)(DT)(DA)(DG)(DG)(DG)(DG)(DA)(DG)(DA)(DA)(DT)(DT)(DG)(DG)(DC)(DC)(DA)

CTGCCCTTGCAAAGTCAGCAGCACGTAGGGGAGAATTGGCCA
DNA #4 42 bases

(DT)(DG)(DG)(DC)(DC)(DA)(DA)(DT)(DT)(DC)(DT)(DC)(DC)(DC)(DC)(DT)(DA)(DC)(DG)(DT)(DG)(DC)(DT)(DG)(DC)(DT)(DG)(DA)(DC)(DT)(DT)(DT)(DG)(DC)(DA)(DA)(DG)(DG)(DG)(DC)(DA)(DG)

TGGCCAATTCTCCCCTACGTGCTGCTGACTTTGCAAGGGCAG
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Reference