2025-05-31_00000021|hard|8ZQB

Cryo-EM structure of Cas12X with crRNA; Electron microscopy 3.65Å
Protein #1 914 residues (86% resolved)

HHHHHHMPSYKSSRVLVRDVPEELVDHYERSHRVAAFFMRLLLAMRREPYSLRMRDGTEREVDLDETDDFLRSAGCEEPDAVSDDLRSFALAVLHQDNPKKRAFLESENCVSILCLEKSASGTRYYKRPGYQLLKKAIEEEWGWDKFEASLLDERTGEVAEKFAALSMEDWRRFFAARDPDDLGRELLKTDTREGMAAALRLRERGVFPVSVPEHLDLDSLKAAMASAAERLKSWLACNQRAVDEKSELRKRFEEALDGVDPEKYALFEKFAAELQQADYNVTKKLVLAVSAKFPATEPSEFKRGVEILKEDGYKPLWEDFRELGFVYLAERKWERRRGGAAVTLCDADDSPIKVRFGLTGRGRKFVLSAAGSRFLITVKLPCGDVGLTAVPSRYFWNPSVGRTTSNSFRIEFTKRTTENRRYVGEVKEIGLVRQRGRYYFFIDYNFDPEEVSDETKVGRAFFRAPLNESRPKPKDKLTVMGIDLGINPAFAFAVCTLGECQDGIRSPVAKMEDVSFDSTGLRGGIGSQKLHREMHNLSDRCFYGARYIRLSKKLRDRGALNDIEARLLEEKYIPGFRIVHIEDADERRRTVGRTVKEIKQEYKRIRHQFYLRYHTSKRDRTELISAEYFRMLFLVKNLRNLLKSWNRYHWTTGDRERRGGNPDELKSYVRYYNNLRMDTLKKLTCAIVRTAKEHGATLVAMENIQRVDRDDEVKRRKENSLLSLWAPGMVLERVEQELKNEGILAWEVDPRHTSQTSCITDEFGYRSLVAKDTFYFEQDRKIHRIDADVNAAINIARRFLTRYRSLTQLWASLLDDGRYLVNVTRQHERAYLELQTGAPAATLNPTAEASYELVGLSPEEEELAQTRIKRKKREPFYRHEGVWLTREKHREQVHELRNQVLALGNAKIPEIRT

HHHHHHMPSYKSSRVLVRDVPEELVDHYERSHRVAAFFMRLLLAMRREPYSLRMRDGTEREVDLDETDDFLRSAGCEEPDAVSDDLRSFALAVLHQDNPKKRAFLESENCVSILCLEKSASGTRYYKRPGYQLLKKAIEEEWGWDKFEASLLDERTGEVAEKFAALSMEDWRRFFAARDPDDLGRELLKTDTREGMAAALRLRERGVFPVSVPEHLDLDSLKAAMASAAERLKSWLACNQRAVDEKSELRKRFEEALDGVDPEKYALFEKFAAELQQADYNVTKKLVLAVSAKFPATEPSEFKRGVEILKEDGYKPLWEDFRELGFVYLAERKWERRRGGAAVTLCDADDSPIKVRFGLTGRGRKFVLSAAGSRFLITVKLPCGDVGLTAVPSRYFWNPSVGRTTSNSFRIEFTKRTTENRRYVGEVKEIGLVRQRGRYYFFIDYNFDPEEVSDETKVGRAFFRAPLNESRPKPKDKLTVMGIDLGINPAFAFAVCTLGECQDGIRSPVAKMEDVSFDSTGLRGGIGSQKLHREMHNLSDRCFYGARYIRLSKKLRDRGALNDIEARLLEEKYIPGFRIVHIEDADERRRTVGRTVKEIKQEYKRIRHQFYLRYHTSKRDRTELISAEYFRMLFLVKNLRNLLKSWNRYHWTTGDRERRGGNPDELKSYVRYYNNLRMDTLKKLTCAIVRTAKEHGATLVAMENIQRVDRDDEVKRRKENSLLSLWAPGMVLERVEQELKNEGILAWEVDPRHTSQTSCITDEFGYRSLVAKDTFYFEQDRKIHRIDADVNAAINIARRFLTRYRSLTQLWASLLDDGRYLVNVTRQHERAYLELQTGAPAATLNPTAEASYELVGLSPEEEELAQTRIKRKKREPFYRHEGVWLTREKHREQVHELRNQVLALGNAKIPEIRT
RNA #2 60 bases

GUGCUGCUGUCUCCCAGACGGGAGGCAGAACUGCACCUUCCAUCAGAGAACCUCACUGCG

GUGCUGCUGUCUCCCAGACGGGAGGCAGAACUGCACCUUCCAUCAGAGAACCUCACUGCG
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Reference