2025-05-10_00000387|hard|9R2E

Structure of ARGX-121 Fab fragment in complex with the Fc fragment of IgA1; X-ray diffraction 2.54Å
Protein #1 244 residues (92% resolved)

MGWSCIILFLVATATGVHSEVQLLESGGGLVQPGGSLRLSCAASGFTSSNYLMSWVRQAPGKGLEWVSSIYHYGHNAYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKVDSAYDFGSWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH

MGWSCIILFLVATATGVHSEVQLLESGGGLVQPGGSLRLSCAASGFTSSNYLMSWVRQAPGKGLEWVSSIYHYGHNAYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKVDSAYDFGSWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH
Protein #2 235 residues (91% resolved)

MGWSCIILFLVATATGVHSQSVLTQPPSVSGAPGQRVTISCAGTSSDIGGRTYVSWYQQLPGTAPKLLIYKVTIRASGVPDRFSGSKSGTSASLAITGLQAEDEADYYCASHRSNNNIVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS

MGWSCIILFLVATATGVHSQSVLTQPPSVSGAPGQRVTISCAGTSSDIGGRTYVSWYQQLPGTAPKLLIYKVTIRASGVPDRFSGSKSGTSASLAITGLQAEDEADYYCASHRSNNNIVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS
Protein #3 213 residues (97% resolved)

CHPRLSLHRPALEDLLLGSEANLTCTLTGLRDASGVTFTWTPSSGKSAVQGPPERDLCGCYSVSSVLPGCAEPWNHGKTFTCTAAYPESKTPLTATLSKSGNTFRPEVHLLPPPSEELALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYLTWASRQEPSQGTTTFAVTSILRVAAEDWKKGDTFSCMVGHEALPLAFTQKTIDRLAGK

CHPRLSLHRPALEDLLLGSEANLTCTLTGLRDASGVTFTWTPSSGKSAVQGPPERDLCGCYSVSSVLPGCAEPWNHGKTFTCTAAYPESKTPLTATLSKSGNTFRPEVHLLPPPSEELALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYLTWASRQEPSQGTTTFAVTSILRVAAEDWKKGDTFSCMVGHEALPLAFTQKTIDRLAGK
Non polymer #4 EDO

InChI=1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

C(CO)O
Non polymer #5 MG

InChI=1S/Mg/q+2

[Mg+2]
Non polymer #6 PEG

InChI=1S/C4H10O3/c5-1-3-7-4-2-6/h5-6H,1-4H2

C(COCCO)O
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Reference