2025-05-10_00000188
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ligand
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9DOM
PVTX-405: A Potent, Highly Selective, and Orally Efficacious Molecular Glue Degrader of IKZF2 for Cancer Immunotherapy;
X-ray diffraction 1.69Å
Protein #1
111 residues (98% resolved)
Raw Sequence ...
GPSTSLSCKQCQETEITTKNEIFSLSLSGPMAAYVNPHGYVHETLTVYKASNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTI
Canonical Sequence ...
GPSTSLSCKQCQETEITTKNEIFSLSLSGPMAAYVNPHGYVHETLTVYKASNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTI
Protein #2
30 residues (90% resolved)
Raw Sequence ...
GGERPFHCNQCGASFTQKGNLLRHIKLHSG
Canonical Sequence ...
GGERPFHCNQCGASFTQKGNLLRHIKLHSG
Non polymer #3
A1A8N
InChI=1S/C26H27N3O4/c30-22-9-8-21(24(31)27-22)29-15-19-18(25(29)32)6-7-20-23(19)33-16-26(20)10-12-28(13-11-26)14-17-4-2-1-3-5-17/h1-7,21H,8-16H2,(H,27,30,31)/t21-/m0/s1
InChI=1S/C26H27N3O4/c30-22-9-8-21(24(31)27-22)29-15-19-18(25(29)32)6-7-20-23(19)33-16-26(20)10-12-28(13-11-26)14-17-4-2-1-3-5-17/h1-7,21H,8-16H2,(H,27,30,31)/t21-/m0/s1
SMILES: c1ccc(cc1)CN2CCC3(CC2)COc4c3ccc5c4CN(C5=O)[C@H]6CCC(=O)NC6=O
c1ccc(cc1)CN2CCC3(CC2)COc4c3ccc5c4CN(C5=O)[C@H]6CCC(=O)NC6=O
Non polymer #4
ZN
InChI=1S/Zn/q+2
InChI=1S/Zn/q+2
SMILES: [Zn+2]
[Zn+2]
Biounit #1
hetero-1-1-mer
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Biounit #2
hetero-1-1-mer
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Biounit #3
hetero-1-1-mer
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Biounit #4
hetero-1-1-mer
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Model
Reference
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