2025-04-19_00000041
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ligand
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7IAO
Group deposition of ZIKV NS2B-NS3 protease in complex with inhibitors from ASAP Discovery Consortium -- Crystal Structure of ZIKV NS2B-NS3 protease in complex with ASAP-0029543-001;
X-ray diffraction 2.24Å
Protein #1
46 residues (83% resolved)
Raw Sequence ...
SMGKSVDMYIERAGDITWEKDAEVTGNSPRLDVALDESGDFSLVEE
Canonical Sequence ...
SMGKSVDMYIERAGDITWEKDAEVTGNSPRLDVALDESGDFSLVEE
Protein #2
168 residues (92% resolved)
Raw Sequence ...
MKEVKKGETTDGVYRVMTRRLLGSTQVGVGVMQEGVFHTMWHVTKGAALRSGEGRLDPYWGDVKQDLVSYCGPWKLDAAWDGLSEVQLLAVPPGERAKNIQTLPGIFKTKDGDIGAVALDYPAGTSGSPILDKCGRVIGLYGNGVVIKNGSYVSAITQGKREEETPVE
Canonical Sequence ...
MKEVKKGETTDGVYRVMTRRLLGSTQVGVGVMQEGVFHTMWHVTKGAALRSGEGRLDPYWGDVKQDLVSYCGPWKLDAAWDGLSEVQLLAVPPGERAKNIQTLPGIFKTKDGDIGAVALDYPAGTSGSPILDKCGRVIGLYGNGVVIKNGSYVSAITQGKREEETPVE
Non polymer #3
A1B8X
InChI=1S/C23H26ClN5O2/c24-17-8-19(20-13-27-29-21(20)9-17)22(23(30)26-10-14-3-5-31-6-4-14)28-18-2-1-15-11-25-12-16(15)7-18/h1-2,7-9,13-14,22,25,28H,3-6,10-12H2,(H,26,30)(H,27,29)/t22-/m1/s1
InChI=1S/C23H26ClN5O2/c24-17-8-19(20-13-27-29-21(20)9-17)22(23(30)26-10-14-3-5-31-6-4-14)28-18-2-1-15-11-25-12-16(15)7-18/h1-2,7-9,13-14,22,25,28H,3-6,10-12H2,(H,26,30)(H,27,29)/t22-/m1/s1
SMILES: c1cc2c(cc1N[C@H](c3cc(cc4c3cn[nH]4)Cl)C(=O)NCC5CCOCC5)CNC2
c1cc2c(cc1N[C@H](c3cc(cc4c3cn[nH]4)Cl)C(=O)NCC5CCOCC5)CNC2
Non polymer #4
DMS
InChI=1S/C2H6OS/c1-4(2)3/h1-2H3
InChI=1S/C2H6OS/c1-4(2)3/h1-2H3
SMILES: CS(=O)C
CS(=O)C
Biounit #1
hetero-1-1-mer
Download coordinates
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Model
Reference
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