2025-04-12_00000038|hard|8WRQ

Cryo-EM structure of Cas12-1 with 14 nt complementary heteroduplex; Electron microscopy 3.05Å
Protein #1 737 residues (74% resolved)

MTPKTETPVGALIKKFFPGKRFQKNYLKDAGKKLKREGEAAAVEYLSGKQEDHPANFCPPAKVNILAQSRPLSEWPINLVSKGVQEYVYGLTAAEREANGDFGTSRKSLDRWFARTGVPTHGYTTVQGLNLILRHTFNRYDGVIKKVETRNEKRRSKATRINVSREADGLPPIEAEPEETAFGPDGKLKERPGINPSIYCYQQVSPVPYNPAKHPALPFSGVDPGAPLPLGTPNRLSIPKGQPGYVPEWQRPHLSTKNKRIRKWYARANWRRKPGRKSVLDEAKLKEAALKEAIPIIVTIGKDWIVMDARGLLRAVYWRGIAKPGLSLKELLGFFSGDPVLDPKRGIATFTFKLGAVAVHSRKPTRGKKSKELLLSMTAEKPHVGLVAIDLGQTNPVAAEFSRVKREGETLQAEPLGQIVLPDDLVKDLTRYRRAWDATEEQIKAEAIVQLPEECRAEVVKVNQMSAEETKHLILDRGVSGDLPWEKMTSNTTFISDHLLAKGVTDQVFFEKKSKGKKKGTETVKRKDYGWVKLLRPRLSQETRKAVNDKTWELKRASTEYVRLSRRKTELARRCVNYIVRETKRWTQCEDIAIVIEDLNVRFFHGSGERPDGWDNFFISKRENRWFIQVLHKAFSDLALHRGLPVIEANPARTSITCIRCGHCDRNNRHGEMFLCLSCNDLRHADREIATRNLTRVAVTGEMIPRRIEPGEQSGDTKKARSARKGKKAVISKREAA

MTPKTETPVGALIKKFFPGKRFQKNYLKDAGKKLKREGEAAAVEYLSGKQEDHPANFCPPAKVNILAQSRPLSEWPINLVSKGVQEYVYGLTAAEREANGDFGTSRKSLDRWFARTGVPTHGYTTVQGLNLILRHTFNRYDGVIKKVETRNEKRRSKATRINVSREADGLPPIEAEPEETAFGPDGKLKERPGINPSIYCYQQVSPVPYNPAKHPALPFSGVDPGAPLPLGTPNRLSIPKGQPGYVPEWQRPHLSTKNKRIRKWYARANWRRKPGRKSVLDEAKLKEAALKEAIPIIVTIGKDWIVMDARGLLRAVYWRGIAKPGLSLKELLGFFSGDPVLDPKRGIATFTFKLGAVAVHSRKPTRGKKSKELLLSMTAEKPHVGLVAIDLGQTNPVAAEFSRVKREGETLQAEPLGQIVLPDDLVKDLTRYRRAWDATEEQIKAEAIVQLPEECRAEVVKVNQMSAEETKHLILDRGVSGDLPWEKMTSNTTFISDHLLAKGVTDQVFFEKKSKGKKKGTETVKRKDYGWVKLLRPRLSQETRKAVNDKTWELKRASTEYVRLSRRKTELARRCVNYIVRETKRWTQCEDIAIVIEDLNVRFFHGSGERPDGWDNFFISKRENRWFIQVLHKAFSDLALHRGLPVIEANPARTSITCIRCGHCDRNNRHGEMFLCLSCNDLRHADREIATRNLTRVAVTGEMIPRRIEPGEQSGDTKKARSARKGKKAVISKREAA
RNA #2 56 bases

CCGUCAACGUUCAACGCUUGCUCGGUUCGCCGAGACUCCCCUACGUGCUGCUGAAG

CCGUCAACGUUCAACGCUUGCUCGGUUCGCCGAGACUCCCCUACGUGCUGCUGAAG
DNA #3 42 bases

(DC)(DT)(DG)(DC)(DC)(DC)(DT)(DT)(DG)(DC)(DA)(DA)(DG)(DA)(DA)(DG)(DT)(DC)(DC)(DA)(DG)(DC)(DA)(DC)(DG)(DT)(DA)(DG)(DG)(DG)(DG)(DA)(DG)(DA)(DA)(DT)(DT)(DG)(DG)(DC)(DC)(DA)

CTGCCCTTGCAAGAAGTCCAGCACGTAGGGGAGAATTGGCCA
DNA #4 42 bases

(DT)(DG)(DG)(DC)(DC)(DA)(DA)(DT)(DT)(DC)(DT)(DC)(DC)(DC)(DC)(DT)(DA)(DC)(DG)(DT)(DG)(DC)(DT)(DG)(DG)(DA)(DC)(DT)(DT)(DC)(DT)(DT)(DG)(DC)(DA)(DA)(DG)(DG)(DG)(DC)(DA)(DG)

TGGCCAATTCTCCCCTACGTGCTGGACTTCTTGCAAGGGCAG
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Reference