2025-03-22_00000351|medium|9NSR

Crystal structure of bifunctional farnesyl/geranylgeranyl pyrophosphate synthase (FPPS/GGPPS) from Plasmodium falciparum in complex with MMV019313; X-ray diffraction 3.25Å
Protein #1 378 residues (88% resolved)

GPMENEQNNQDSENGLDYFRSMYDRYRDVFINHINDYVLEDDIKIIISKYYKLLFDYNCLGGKNNRGILVILIYEYVKNRDINCNEWEKVACIAWCIEILQASFLVADDIMDKGETRRNKHCWYLLKDVEIKNAVNDVFLLYNAIYKLLDVYLRNDNCYLDLITSFREATLKTIVGQHLDTNIFSDKYSHIDKDIDVNNINISQENKININMLNFKVYQNIIIHKTAYYSFFLPIVCGMQMGGISLDNLLYKKVENIAILMGEYFQVHDDYIDTFGDSKKTGKVGSDIQNNKLTWPLIKAFELCSQPEKEDIIRNYGKDNVTCIKFINDIYEHYNIRDHYVEYEKKQKMKILEAINQLHHEGIEYVLKYVMDILFTGA

GPMENEQNNQDSENGLDYFRSMYDRYRDVFINHINDYVLEDDIKIIISKYYKLLFDYNCLGGKNNRGILVILIYEYVKNRDINCNEWEKVACIAWCIEILQASFLVADDIMDKGETRRNKHCWYLLKDVEIKNAVNDVFLLYNAIYKLLDVYLRNDNCYLDLITSFREATLKTIVGQHLDTNIFSDKYSHIDKDIDVNNINISQENKININMLNFKVYQNIIIHKTAYYSFFLPIVCGMQMGGISLDNLLYKKVENIAILMGEYFQVHDDYIDTFGDSKKTGKVGSDIQNNKLTWPLIKAFELCSQPEKEDIIRNYGKDNVTCIKFINDIYEHYNIRDHYVEYEKKQKMKILEAINQLHHEGIEYVLKYVMDILFTGA
Non polymer #2 A1B0W

InChI=1S/C22H27N3O2S/c1-24-18-10-5-4-9-16(18)20-17(22(24)27)15-19(28-20)21(26)23-11-8-14-25-12-6-2-3-7-13-25/h4-5,9-10,15H,2-3,6-8,11-14H2,1H3,(H,23,26)

CN1c2ccccc2-c3c(cc(s3)C(=O)NCCCN4CCCCCC4)C1=O
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Reference