2025-03-15_00000260|medium|9F19

Human USP30 chimera in complex with NK036 inhibitor; X-ray diffraction 2.75Å
Protein #1 317 residues (79% resolved)

GPKGLVPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTLLHLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDGSGSHWKSQHPFGVEFETTMKCTESEEEEVTKGKENQDSLSLSIPAATWGHPLTLDHCLHHFISQEEITKQSPTLQRNALYIKSSKISRLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEDLRLPLAGGRGQAYRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQEVLSSSAYLLFYERV

GPKGLVPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTLLHLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDGSGSHWKSQHPFGVEFETTMKCTESEEEEVTKGKENQDSLSLSIPAATWGHPLTLDHCLHHFISQEEITKQSPTLQRNALYIKSSKISRLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEDLRLPLAGGRGQAYRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQEVLSSSAYLLFYERV
Non polymer #2 A1H8X

InChI=1S/C26H28FN3O5S/c1-26(2,17-31)30-36(34,35)22-14-12-21(13-15-22)28-25(33)23(16-18-6-4-3-5-7-18)29-24(32)19-8-10-20(27)11-9-19/h3-15,23,30-31H,16-17H2,1-2H3,(H,28,33)(H,29,32)

CC(C)(CO)NS(=O)(=O)c1ccc(cc1)NC(=O)[C@H](Cc2ccccc2)NC(=O)c3ccc(cc3)F
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Reference