2025-03-15_00000025|hard|8S7O

M. tuberculosis gyrase holocomplex with 150 bp DNA and BDM71403; Electron microscopy 2.80Å
Protein #1 837 residues (58% resolved)

TDTTLPPDDSLDRIEPVDIEQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDSLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEETLAAVMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRYYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARAGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAIDGDVSDEDLIAREDVVVTITETGYAKRTKTDLYRSQKRGGKGVQGAGLKQDDIVAHFFVCSTHDLILFFTTQGRVYRAKAYDLPEASRTARGQHVANLLAFQPEERIAQVIQIRGYTDAPYLVLATRNGLVKKSKLTDFDSNRSGGIVAVNLRDNDELVGAVLCSAGDDLLLVSANGQSIRFSATDEALRPMGRATSGVQGMRFNIDDRLLSLNVVREGTYLLVATSGGYAKRTAIEEYPVQGRGGKGVLTVMYDRRRGRLVGALIVDDDSELYAVTSGGGVIRTAARQVRKAGRQTKGVRLMNLGEGDTLLAIARNAEESGDDNAVDANGADQTGN

TDTTLPPDDSLDRIEPVDIEQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMFDSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDSLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLRELADAVFWALENHDADEEETLAAVMGRVKGPDFPTAGLIVGSQGTADAYKTGRGSIRMRGVVEVEEDSRGRTSLVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQSSDRVGLRIVIEIKRDAVAKVVINNLYKHTQLQTSFGANMLAIVDGVPRTLRLDQLIRYYVDHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVIALIRASETVDIARAGLIELLDIDEIQAQAILDMQLRRLAALERQRIIDDLAKIEAEIADLEDILAKPERQRGIVRDELAEIVDRHGDDRRTRIIAIDGDVSDEDLIAREDVVVTITETGYAKRTKTDLYRSQKRGGKGVQGAGLKQDDIVAHFFVCSTHDLILFFTTQGRVYRAKAYDLPEASRTARGQHVANLLAFQPEERIAQVIQIRGYTDAPYLVLATRNGLVKKSKLTDFDSNRSGGIVAVNLRDNDELVGAVLCSAGDDLLLVSANGQSIRFSATDEALRPMGRATSGVQGMRFNIDDRLLSLNVVREGTYLLVATSGGYAKRTAIEEYPVQGRGGKGVLTVMYDRRRGRLVGALIVDDDSELYAVTSGGGVIRTAARQVRKAGRQTKGVRLMNLGEGDTLLAIARNAEESGDDNAVDANGADQTGN
Protein #2 678 residues (28% resolved)

GAMVAAQKKKAQDEYGAASITILEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNAVDEAMAGYATTVNVVLLEDGGVEVADDGRGIPVATHASGIPTVDVVMTQLHAGGKFDSDAYAISGGLHGVGVSVVNALSTRLEVEIKRDGYEWSQVYEKSEPLGLKQGAPTKKTGSTVRFWADPAVFETTEYDFETVARRLQEMAFLNKGLTINLTDERVTQDEVVDEVVSDVAEAPKSASERAAESTAPHKVKSRTFHYPGGLVDFVKHINRTKNAIHSSIVDFSGKGTGHEVEIAMQWNAGYSESVHTFANTINTHEGGTHEEGFRSALTSVVNKYAKDRKLLKDKDPNLTGDDIREGLAAVISVKVSEPQFEGQTKTKLGNTEVKSFVQKVCNEQLTHWFEANPTDAKVVVNKAVSSAQARIAARKARELVRRKSATDIGGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAILPLRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKIVLMADADVDGQHISTLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDPEFAYSDRERDGLLEAGLKAGKKINKEDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVDARRSFITRNAKDVRFLDV

GAMVAAQKKKAQDEYGAASITILEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNAVDEAMAGYATTVNVVLLEDGGVEVADDGRGIPVATHASGIPTVDVVMTQLHAGGKFDSDAYAISGGLHGVGVSVVNALSTRLEVEIKRDGYEWSQVYEKSEPLGLKQGAPTKKTGSTVRFWADPAVFETTEYDFETVARRLQEMAFLNKGLTINLTDERVTQDEVVDEVVSDVAEAPKSASERAAESTAPHKVKSRTFHYPGGLVDFVKHINRTKNAIHSSIVDFSGKGTGHEVEIAMQWNAGYSESVHTFANTINTHEGGTHEEGFRSALTSVVNKYAKDRKLLKDKDPNLTGDDIREGLAAVISVKVSEPQFEGQTKTKLGNTEVKSFVQKVCNEQLTHWFEANPTDAKVVVNKAVSSAQARIAARKARELVRRKSATDIGGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAILPLRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKIVLMADADVDGQHISTLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDPEFAYSDRERDGLLEAGLKAGKKINKEDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVDARRSFITRNAKDVRFLDV
DNA #3 150 bases

(DG)(DT)(DA)(DC)(DC)(DG)(DG)(DA)(DC)(DG)(DT)(DT)(DG)(DC)(DG)(DC)(DC)(DC)(DG)(DT)(DA)(DG)(DG)(DG)(DC)(DT)(DA)(DC)(DG)(DG)(DC)(DG)(DG)(DC)(DC)(DT)(DT)(DC)(DG)(DC)(DT)(DC)(DT)(DT)(DC)(DT)(DT)(DA)(DG)(DT)(DA)(DT)(DT)(DA)(DC)(DC)(DC)(DC)(DT)(DT)(DC)(DC)(DG)(DG)(DT)(DA)(DG)(DG)(DT)(DC)(DG)(DG)(DA)(DG)(DC)(DG)(DC)(DA)(DG)(DC)(DG)(DC)(DT)(DT)(DG)(DC)(DG)(DG)(DT)(DC)(DG)(DT)(DT)(DC)(DT)(DG)(DC)(DA)(DT)(DC)(DG)(DG)(DG)(DT)(DC)(DG)(DC)(DG)(DC)(DA)(DG)(DC)(DC)(DG)(DG)(DC)(DG)(DG)(DT)(DA)(DC)(DG)(DG)(DC)(DC)(DG)(DC)(DT)(DA)(DT)(DT)(DA)(DC)(DC)(DG)(DG)(DA)(DC)(DG)(DA)(DA)(DG)(DA)(DG)(DC)(DG)(DG)(DC)(DT)(DT)

GTACCGGACGTTGCGCCCGTAGGGCTACGGCGGCCTTCGCTCTTCTTAGTATTACCCCTTCCGGTAGGTCGGAGCGCAGCGCTTGCGGTCGTTCTGCATCGGGTCGCGCAGCCGGCGGTACGGCCGCTATTACCGGACGAAGAGCGGCTT
DNA #4 150 bases

(DA)(DA)(DG)(DC)(DC)(DG)(DC)(DT)(DC)(DT)(DT)(DC)(DG)(DT)(DC)(DC)(DG)(DG)(DT)(DA)(DA)(DT)(DA)(DG)(DC)(DG)(DG)(DC)(DC)(DG)(DT)(DA)(DC)(DC)(DG)(DC)(DC)(DG)(DG)(DC)(DT)(DG)(DC)(DG)(DC)(DG)(DA)(DC)(DC)(DC)(DG)(DA)(DT)(DG)(DC)(DA)(DG)(DA)(DA)(DC)(DG)(DA)(DC)(DC)(DG)(DC)(DA)(DA)(DG)(DC)(DG)(DC)(DT)(DG)(DC)(DG)(DC)(DT)(DC)(DC)(DG)(DA)(DC)(DC)(DT)(DA)(DC)(DC)(DG)(DG)(DA)(DA)(DG)(DG)(DG)(DG)(DT)(DA)(DA)(DT)(DA)(DC)(DT)(DA)(DA)(DG)(DA)(DA)(DG)(DA)(DG)(DC)(DG)(DA)(DA)(DG)(DG)(DC)(DC)(DG)(DC)(DC)(DG)(DT)(DA)(DG)(DC)(DC)(DC)(DT)(DA)(DC)(DG)(DG)(DG)(DC)(DG)(DC)(DA)(DA)(DC)(DG)(DT)(DC)(DC)(DG)(DG)(DT)(DA)(DC)

AAGCCGCTCTTCGTCCGGTAATAGCGGCCGTACCGCCGGCTGCGCGACCCGATGCAGAACGACCGCAAGCGCTGCGCTCCGACCTACCGGAAGGGGTAATACTAAGAAGAGCGAAGGCCGCCGTAGCCCTACGGGCGCAACGTCCGGTAC
Non polymer #5 A1H5Q

InChI=1S/C22H21N7O2S/c1-31-21-5-3-16-22(26-21)18(7-9-24-16)29-12-15(27-28-29)6-8-23-11-14-2-4-19-17(10-14)25-20(30)13-32-19/h2-5,7,9-10,12,23H,6,8,11,13H2,1H3,(H,25,30)

COc1ccc2c(n1)c(ccn2)n3cc(nn3)CCNCc4ccc5c(c4)NC(=O)CS5
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Reference