2025-03-08_00000391|hard|9MW6

Cryo-EM structure of ancestral Dicer helicase bound to 27-bp dsRNA; Electron microscopy 3.40Å
Protein #1 652 residues (82% resolved)

MDETDEDEFTPRPYQVELLERAMKKNTIVCLGTGSGKTFIAVMLIKELAHEIRGPFNEGGKRTFFLVNTVPLVNQQAKVIRKHTSLKVGEYVGDMGVDSWNKEKWNQEFEKHQVLVMTAQIFLDILNHGFISLSQVNLLIFDECHHAVKNHPYRQIMRHYKNLEQNDRPRILGLTASVINSKCKPNQVEKKIKELEATLNSRVVTASDLEEVAVQKYATKPKEIIVSYNSDRKSDTSEVIENIINQALEQLSNIEETSNLNDTNSLKQIKKVLRDIKNILDELGPWCAHRVIKSRIRQLEKRESETAEELRTIRELLQSIFEQIINVLKNLEKLQKNNSVEFVSPKVKKLLEILKQYFSNNNNSSKELCGIIFVERRYTAYVLYKLLNELSAKRDDDFSFIKCDFVVGHNSSPSSKEKSTEMNSKKQKEVLKKFRKGECNLLVATSVVEEGIDIPKCNLVVRFDLPKNFRSYVQSKGRARAKNSKYIIMVEEDEKNKFQEDLNQYQEIEKILLRLCHNRDAPSEEDFDSFEDELLPPYMPYGTDGPRVTMSSAISLLHRYCSKLPSDRFTTLTPKFTYIEQNNEEENKMFRCTLRLPINSPLREPITGQPMPSKKLAKRSAALEACKKLHEMGELDDHLLPVKISRKNAELK

MDETDEDEFTPRPYQVELLERAMKKNTIVCLGTGSGKTFIAVMLIKELAHEIRGPFNEGGKRTFFLVNTVPLVNQQAKVIRKHTSLKVGEYVGDMGVDSWNKEKWNQEFEKHQVLVMTAQIFLDILNHGFISLSQVNLLIFDECHHAVKNHPYRQIMRHYKNLEQNDRPRILGLTASVINSKCKPNQVEKKIKELEATLNSRVVTASDLEEVAVQKYATKPKEIIVSYNSDRKSDTSEVIENIINQALEQLSNIEETSNLNDTNSLKQIKKVLRDIKNILDELGPWCAHRVIKSRIRQLEKRESETAEELRTIRELLQSIFEQIINVLKNLEKLQKNNSVEFVSPKVKKLLEILKQYFSNNNNSSKELCGIIFVERRYTAYVLYKLLNELSAKRDDDFSFIKCDFVVGHNSSPSSKEKSTEMNSKKQKEVLKKFRKGECNLLVATSVVEEGIDIPKCNLVVRFDLPKNFRSYVQSKGRARAKNSKYIIMVEEDEKNKFQEDLNQYQEIEKILLRLCHNRDAPSEEDFDSFEDELLPPYMPYGTDGPRVTMSSAISLLHRYCSKLPSDRFTTLTPKFTYIEQNNEEENKMFRCTLRLPINSPLREPITGQPMPSKKLAKRSAALEACKKLHEMGELDDHLLPVKISRKNAELK
RNA #2 27 bases

AUACGUCCUGAUAGUUAGUAUCCAUCG

AUACGUCCUGAUAGUUAGUAUCCAUCG
RNA #3 27 bases

CGAUGGAUACUAACUAUCAGGACGUAU

CGAUGGAUACUAACUAUCAGGACGUAU
Download coordinates
Reference