2025-03-08_00000061|ligand|8YMG

BRD4-BD1 in complex with 7-[4-chloro-1-(tetrahydropyran-4-ylmethyl)imidazol-2-yl]-5-methyl-2-{[(2R)-2-methyl-4-methylsulfonyl-piperazin-1-yl]methyl}furo[3,2-c]pyridin-4-one; X-ray diffraction 1.01Å
Protein #1 128 residues (98% resolved)

GSMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE

GSMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE
Non polymer #2 A1LZC

InChI=1S/C24H32ClN5O5S/c1-16-11-30(36(3,32)33)7-6-28(16)13-18-10-19-22(35-18)20(14-27(2)24(19)31)23-26-21(25)15-29(23)12-17-4-8-34-9-5-17/h10,14-17H,4-9,11-13H2,1-3H3/t16-/m1/s1

C[C@@H]1CN(CCN1Cc2cc3c(o2)C(=CN(C3=O)C)c4nc(cn4CC5CCOCC5)Cl)S(=O)(=O)C
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Reference