2025-03-08_00000025|ligand|8S76

Soluble epoxide hydrolase in complex with PROTAC JSF67; X-ray diffraction 1.48Å
Protein #1 367 residues (87% resolved)

MGSSHHHHHHSSGLVPRGSHMASMLNTPAPLPTSCNPSDMSHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLDSDARNPPVVSKMLLEHHHHHH

MGSSHHHHHHSSGLVPRGSHMASMLNTPAPLPTSCNPSDMSHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLDSDARNPPVVSKMLLEHHHHHH
Non polymer #2 A1H5M

InChI=1S/C48H45F4N9O10S/c49-33-4-1-3-29(21-33)26-59-15-14-30-22-31(7-11-40(30)59)44(64)53-25-32-6-8-35(24-39(32)48(50,51)52)57-72(68,69)20-2-5-36-27-60(58-56-36)16-17-70-18-19-71-28-43(63)54-34-9-10-37-38(23-34)47(67)61(46(37)66)41-12-13-42(62)55-45(41)65/h1,3-4,6-11,14-15,21-24,27,41,57H,2,5,12-13,16-20,25-26,28H2,(H,53,64)(H,54,63)(H,55,62,65)

c1cc(cc(c1)F)Cn2ccc3c2ccc(c3)C(=O)NCc4ccc(cc4C(F)(F)F)NS(=O)(=O)CCCc5cn(nn5)CCOCCOCC(=O)Nc6ccc7c(c6)C(=O)N(C7=O)C8CCC(=O)NC8=O
Non polymer #3 EDO

InChI=1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

C(CO)O
Non polymer #4 PEG

InChI=1S/C4H10O3/c5-1-3-7-4-2-6/h5-6H,1-4H2

C(COCCO)O
Download coordinates
Download coordinates
Reference