2025-03-01_00000248|ligand|9FZQ

Proton conductance by human uncoupling protein 1 is inhibited by both purine and pyrimidine nucleotides; Electron microscopy 3.03Å
Protein #1 310 residues (93% resolved)

TSEDGGLTASDVHPTLGVQLFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITAVVKTEGRMKLYSGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIGQPTEVVKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINCTELVTYDLMKEAFVKNNILADDVPCHLVSALIAGFCATAMSSPVDVVKTRFINSPPGQYKSVPNCAMKVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLKRELSKSRQTMDCAT

TSEDGGLTASDVHPTLGVQLFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITAVVKTEGRMKLYSGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIGQPTEVVKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINCTELVTYDLMKEAFVKNNILADDVPCHLVSALIAGFCATAMSSPVDVVKTRFINSPPGQYKSVPNCAMKVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLKRELSKSRQTMDCAT
Protein #2 124 residues (100% resolved)

QVQLVESGGGLVQAGDSLRLSCAASGLTLKNYAMGWFRQAPGKEHEFVAVISWSGSGTSYADSVEGRFTISRDNAKNTAFLQMSSLKPEDTAVYYCAARDGGYGSRWPDEYTYWGQGTQVTVPP

QVQLVESGGGLVQAGDSLRLSCAASGLTLKNYAMGWFRQAPGKEHEFVAVISWSGSGTSYADSVEGRFTISRDNAKNTAFLQMSSLKPEDTAVYYCAARDGGYGSRWPDEYTYWGQGTQVTVPP
Protein #3 128 residues (99% resolved)

QVQLVESGGGLVQAGGSLRLSCAPSGRTSSTYTMGWFRQAPGKEREFVAAISWTGTPYYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCAAARPGLFIFVSDYARTAKYDYWGQGTQVTVPP

QVQLVESGGGLVQAGGSLRLSCAPSGRTSSTYTMGWFRQAPGKEREFVAAISWTGTPYYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCAAARPGLFIFVSDYARTAKYDYWGQGTQVTVPP
Non polymer #4 CDL

InChI=1S/C81H158O17P2/c1-5-9-13-17-21-25-29-33-37-41-45-49-53-57-61-65-78(83)91-71-76(97-80(85)67-63-59-55-51-47-43-39-35-31-27-23-19-15-11-7-3)73-95-99(87,88)93-69-75(82)70-94-100(89,90)96-74-77(98-81(86)68-64-60-56-52-48-44-40-36-32-28-24-20-16-12-8-4)72-92-79(84)66-62-58-54-50-46-42-38-34-30-26-22-18-14-10-6-2/h75-77,82H,5-74H2,1-4H3,(H,87,88)(H,89,90)/p-2/t76-,77-/m1/s1

CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(=O)([O-])OCC(COP(=O)([O-])OC[C@@H](COC(=O)CCCCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCCCC)O)OC(=O)CCCCCCCCCCCCCCCCC
Non polymer #5 UTP

InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1

C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO[P@@](=O)(O)O[P@@](=O)(O)OP(=O)(O)O)O)O
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