2025-03-01_00000005|ligand|7H65

THE 1.8 A CRYSTAL STRUCTURE OF HUMAN CHYMASE IN COMPLEX WITH N-[1-[2-[[2-hydroxy-3-methyl-3-(4-methylphenyl)-4-oxocyclobuten-1-yl]-phenylmethyl]-6-methyl-1H-indol-3-yl]-2-methylpropan-2-yl]acetamide; X-ray diffraction 1.80Å
Protein #1 226 residues (97% resolved)

IIGGTESKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQKNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWINQILQAN

IIGGTESKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQKNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWINQILQAN
Non polymer #2 A1AO1

InChI=1S/C34H36N2O3/c1-20-12-15-24(16-13-20)34(6)31(38)29(32(34)39)28(23-10-8-7-9-11-23)30-26(19-33(4,5)36-22(3)37)25-17-14-21(2)18-27(25)35-30/h7-18,28,35,38H,19H2,1-6H3,(H,36,37)/t28-,34-/m0/s1

Cc1ccc(cc1)[C@]2(C(=C(C2=O)[C@@H](c3ccccc3)c4c(c5ccc(cc5[nH]4)C)CC(C)(C)NC(=O)C)O)C
Non polymer #3 DMS

InChI=1S/C2H6OS/c1-4(2)3/h1-2H3

CS(=O)C
Non polymer #4 ZN

InChI=1S/Zn/q+2

[Zn+2]
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Reference