2025-02-08_00000220|ligand|9DFW

X-ray crystal structure of an engineered Viperin-like enzyme from T. virens with bound CTP and SAM; X-ray diffraction 1.68Å
Protein #1 317 residues (93% resolved)

MHHHHHHSSGVDLGTENLYFQSMGQVPVSVNYHFSRKCNKECLFCFHTATTSHVEKPENAKRGLTLLKQAGMKKINFAGGEPFLYPKFLGEMIDFCKETLQLESVSIVTNGSLVKEQFLQKHGRNIDILAVSCDSFNEATNIKIGRGSGDNVQKLYEIGSWCQKYDIKFKLNTVVNKFNHLEDMNDHLNALQPFRWKCFQVLIIEGENDSDKTLRNAHSLTISDDEFDRFCERHSSQTCLVPEPNRLMAKSYLILDEYMRFLNCTGGRKDPSKSILEVGVQQALQAVFWDEEAFVERGGIYDWNKSSCSSDSKDLEW

MHHHHHHSSGVDLGTENLYFQSMGQVPVSVNYHFSRKCNKECLFCFHTATTSHVEKPENAKRGLTLLKQAGMKKINFAGGEPFLYPKFLGEMIDFCKETLQLESVSIVTNGSLVKEQFLQKHGRNIDILAVSCDSFNEATNIKIGRGSGDNVQKLYEIGSWCQKYDIKFKLNTVVNKFNHLEDMNDHLNALQPFRWKCFQVLIIEGENDSDKTLRNAHSLTISDDEFDRFCERHSSQTCLVPEPNRLMAKSYLILDEYMRFLNCTGGRKDPSKSILEVGVQQALQAVFWDEEAFVERGGIYDWNKSSCSSDSKDLEW
Non polymer #2 CTP

InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1

C1=CN(C(=O)N=C1N)[C@H]2[C@@H]([C@@H]([C@H](O2)CO[P@](=O)(O)O[P@](=O)(O)OP(=O)(O)O)O)O
Non polymer #3 EPE

InChI=1S/C8H18N2O4S/c11-7-5-9-1-3-10(4-2-9)6-8-15(12,13)14/h11H,1-8H2,(H,12,13,14)

C1CN(CCN1CCO)CCS(=O)(=O)O
Non polymer #4 MG

InChI=1S/Mg/q+2

[Mg+2]
Non polymer #5 SAM

InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/t7-,8+,10+,11+,14+,27-/m0/s1

C[S@@+](CC[C@@H](C(=O)[O-])N)C[C@@H]1[C@H]([C@H]([C@@H](O1)n2cnc3c2ncnc3N)O)O
Non polymer #6 SF4

InChI=1S/4Fe.4S

[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
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Reference