2025-01-18_00000120|hard|9ARL

CryoEM structure of BoNT-NTNH-OrfX2 complex from Clostridium botulinum strain A1-ST7B, major class; Electron microscopy 4.00Å
Protein #1 1296 residues (98% resolved)

MPFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHQLIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNAKTFLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTGLFEFYKLLCVRGIITSKTKSLDKGYNKALNDLCIKVNNWDLFFSPSEDNFTNDLNKGEEITSDTNIEAAEENISLDLIQQYYLTFNFDNEPENISIENLSSDIIGQLELMPNIERFPNGKKYELDKYTMFHYLRAQEFEHGKSRIALTNSVNEALLNPSRVYTFFSSDYVKKVNKATEAAMFLGWVEQLVYDFTDETSEVSTTDKIADITIIIPYIGPALNIGNMLYKDDFVGALIFSGAVILLEFIPEIAIPVLGTFALVSYIANKVLTVQTIDNALSKRNEKWDEVYKYIVTNWLAKVNTQIDLIRKKMKEALENQAEATKAIINYQYNQYTEEEKNNINFNIDDLSSKLNESINKAMININKFLNQCSVSYLMNSMIPYGVKRLEDFDASLKDALLKYIYDNRGTLIGQVDRLKDKVNNTLSTDIPFQLSKYVDNQRLLSTFTEYIKNIINTSILNLRYESNHLIDLSRYASKINIGSKVNFDPIDKNQIQLFNLESSKIEVILKNAIVYNSMYENFSTSFWIRIPKYFNSISLNNEYTIINCMENNSGWKVSLNYGEIIWTLQDTQEIKQRVVFKYSQMINISDYINRWIFVTITNNRLNNSKIYINGRLIDQKPISNLGNIHASNNIMFKLDGCRDTHRYIWIKYFNLFDKELNEKEIKDLYDNQSNSGILKDFWGDYLQYDKPYYMLNLYDPNKYVDVNNVGIRGYMYLKGPRGSVMTTNIYLNSSLYRGTKFIIKKYASGNKDNIVRNNDRVYINVVVKNKEYRLATNASQAGVEKILSALEIPDVGNLSQVVVMKSKNDQGITNKCKMNLQDNNGNDIGFIGFHQFNNIAKLVASNWYNRQIERSSRTLGCSWEFIPVDDGWGERPL

MPFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHQLIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNAKTFLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTGLFEFYKLLCVRGIITSKTKSLDKGYNKALNDLCIKVNNWDLFFSPSEDNFTNDLNKGEEITSDTNIEAAEENISLDLIQQYYLTFNFDNEPENISIENLSSDIIGQLELMPNIERFPNGKKYELDKYTMFHYLRAQEFEHGKSRIALTNSVNEALLNPSRVYTFFSSDYVKKVNKATEAAMFLGWVEQLVYDFTDETSEVSTTDKIADITIIIPYIGPALNIGNMLYKDDFVGALIFSGAVILLEFIPEIAIPVLGTFALVSYIANKVLTVQTIDNALSKRNEKWDEVYKYIVTNWLAKVNTQIDLIRKKMKEALENQAEATKAIINYQYNQYTEEEKNNINFNIDDLSSKLNESINKAMININKFLNQCSVSYLMNSMIPYGVKRLEDFDASLKDALLKYIYDNRGTLIGQVDRLKDKVNNTLSTDIPFQLSKYVDNQRLLSTFTEYIKNIINTSILNLRYESNHLIDLSRYASKINIGSKVNFDPIDKNQIQLFNLESSKIEVILKNAIVYNSMYENFSTSFWIRIPKYFNSISLNNEYTIINCMENNSGWKVSLNYGEIIWTLQDTQEIKQRVVFKYSQMINISDYINRWIFVTITNNRLNNSKIYINGRLIDQKPISNLGNIHASNNIMFKLDGCRDTHRYIWIKYFNLFDKELNEKEIKDLYDNQSNSGILKDFWGDYLQYDKPYYMLNLYDPNKYVDVNNVGIRGYMYLKGPRGSVMTTNIYLNSSLYRGTKFIIKKYASGNKDNIVRNNDRVYINVVVKNKEYRLATNASQAGVEKILSALEIPDVGNLSQVVVMKSKNDQGITNKCKMNLQDNNGNDIGFIGFHQFNNIAKLVASNWYNRQIERSSRTLGCSWEFIPVDDGWGERPL
Protein #2 1161 residues (99% resolved)

MKINNNFNIDSLIDNRDVAIVRGRKTDTFFKVFQVAPNIWVAPERYYGESLNINEDQKSDGGIYDSNFLLTNDEKDEFLQATVKILQRINNNVIGAKLLSLISTAIPFPYEYKPGDYRQTNYLVSKDNQHYYTANLVIFGPGTNIVENNAVYYKKEDSENGMGTMSEIWFQPFLTYKYDQFYVDPALELIKCLIKSLYYLYGIKPSDDLSIPYRLRSEFNSLEYSELDMVDFLISGGTDYKLLNTNPYWFTDNYFINAPKNFEKYKNDYETKIKNNNDIANSIKLYLEQKFKTNVQDIWELNLSYFSTEFEIMMPEIFNNALNHYHRKEYYVIDYFKNYNINGFINGQIKTILLLSKYNKNIINKPELIVNLINENNSVLMKSNIYGDGLKGTIGNFYAVYKIPYNIGDEYHINSSDSCLDNVDIKEIDNIPPINDADIYPYRKNCDPFTPVYNITETKEINTTIPFPVNYLQAQVTNSNDINLSSDFLKVISSKDRSLVYSFLDNTIDYLDSIKYDGPIDTDKKYYLWLKEIFRNYSFDMTETQEVNTLCGFNKVVPWLGKALNILNTGNSFIEEFKTLGPISLINKKENITMPKIEIDEIPNSMLNLSFKDLSENLFNIFSKNNSYFEKIYYDFLDQWWTQYYSQYFDLICMAKRSVLAQESLIKKIIQKKLSYLIGNSNISSDNLALMNLTTTNTLRDISNESQIAMNNVNNFLNNVAICVFQTNIYPKFISFMEQCINNINKNTREFIQKCTNITENEKLQLINQNIFSSLDFDFLNIENLKSLFNSETGLLIKEETSPYELVLYAFQEPGNNAIGDASGKNTSIEYSKDIGLVYGINSDALYLNGSNQSISFSNDFFENGLTNSFSIYFWLRNLGKDTIKSKLIGSKEDNCGWEIYFQDTGLVFNMIDSNGNEKNIYLSDVSNNSWHYITISVDRLKEQLLIFIDDNLVANESIKEILNIYSSNIISLLSENNPSYIEGLTILNKPTTSQEVLSNYFKVLNNSYIRDSSEERLEYNKTYQLYNYVFSENPIYEIKQNNNIYLTINNTNNLNLQVSKFKLLSINPNKQYVQKLDEVIISVLDNMEKYIDISEDNRLQLIDNKNNAKKMIISNDIFISNCLTLSYNGKYICLSMKDENHNWMICNNDMSKYLYLWSFK

MKINNNFNIDSLIDNRDVAIVRGRKTDTFFKVFQVAPNIWVAPERYYGESLNINEDQKSDGGIYDSNFLLTNDEKDEFLQATVKILQRINNNVIGAKLLSLISTAIPFPYEYKPGDYRQTNYLVSKDNQHYYTANLVIFGPGTNIVENNAVYYKKEDSENGMGTMSEIWFQPFLTYKYDQFYVDPALELIKCLIKSLYYLYGIKPSDDLSIPYRLRSEFNSLEYSELDMVDFLISGGTDYKLLNTNPYWFTDNYFINAPKNFEKYKNDYETKIKNNNDIANSIKLYLEQKFKTNVQDIWELNLSYFSTEFEIMMPEIFNNALNHYHRKEYYVIDYFKNYNINGFINGQIKTILLLSKYNKNIINKPELIVNLINENNSVLMKSNIYGDGLKGTIGNFYAVYKIPYNIGDEYHINSSDSCLDNVDIKEIDNIPPINDADIYPYRKNCDPFTPVYNITETKEINTTIPFPVNYLQAQVTNSNDINLSSDFLKVISSKDRSLVYSFLDNTIDYLDSIKYDGPIDTDKKYYLWLKEIFRNYSFDMTETQEVNTLCGFNKVVPWLGKALNILNTGNSFIEEFKTLGPISLINKKENITMPKIEIDEIPNSMLNLSFKDLSENLFNIFSKNNSYFEKIYYDFLDQWWTQYYSQYFDLICMAKRSVLAQESLIKKIIQKKLSYLIGNSNISSDNLALMNLTTTNTLRDISNESQIAMNNVNNFLNNVAICVFQTNIYPKFISFMEQCINNINKNTREFIQKCTNITENEKLQLINQNIFSSLDFDFLNIENLKSLFNSETGLLIKEETSPYELVLYAFQEPGNNAIGDASGKNTSIEYSKDIGLVYGINSDALYLNGSNQSISFSNDFFENGLTNSFSIYFWLRNLGKDTIKSKLIGSKEDNCGWEIYFQDTGLVFNMIDSNGNEKNIYLSDVSNNSWHYITISVDRLKEQLLIFIDDNLVANESIKEILNIYSSNIISLLSENNPSYIEGLTILNKPTTSQEVLSNYFKVLNNSYIRDSSEERLEYNKTYQLYNYVFSENPIYEIKQNNNIYLTINNTNNLNLQVSKFKLLSINPNKQYVQKLDEVIISVLDNMEKYIDISEDNRLQLIDNKNNAKKMIISNDIFISNCLTLSYNGKYICLSMKDENHNWMICNNDMSKYLYLWSFK
Protein #3 750 residues (75% resolved)

MNNLKPFIYYDWEKTILKNTKENYSINEIIPKTFFMELHGTKITNSTLNGTWKSWNLTNEGEGSYPVLKCIIDDGYLDMNFGASSEKIPLKNVWIKLCMKINPNSDGTYSIPEKSSSFYIKDNSLKISKDNLILDKYLNKLMLSYFKNNIKNIEMFINKSRIQTKVVGDLSLLGWNTENSVSFRTMNEFIKKDNLYPKDFKAVYSYRKMTFTATGTFDSWEMTTGADGRNIRFKCPIKYAVYDLDGDVFNSSTENFLLIQVDLTYFDSKTTINDPTGENDGKQFNLKIKTNDDKLKNVLIVTYNLTDTDGSMSSEDKDFLSLAFRNWFNENIQQFEQIFAYILLDETAKIPEYQWLKPTQISYGSASVETANDEPDLDASIFSAMSMVENNTNSTPSHAVDNRMLQLTKTQAAFGISFPLFIEHFLKQALLSSQFISVDDIVADINTLTITNNKQIIFGKVENSDGKNVDSSLKPGKLKLSLQNNLIVLELFDLTWEQGRGVTGHFDFRQEYELALESKSGKQIPILKVHDEPEIEYYVEEAQWKTNEDMIVSAVVGTVFSMILGASMKLAGSALSKAGKLIRSKATTIKGRKKIYINRSNVRQLRKDSGATEIELERINRRNSSIAAEDARLISNNGTTSIQTLGDMKKKPMSTGQRIAIGAKKIAGTAVMFGAVGLGMNFGEMLINYINAMENNDYSAIPGINSFMQQCIGAMQWPDKDSELKVTFGKLQGIYLLGGTLEKNNKTDNK

MNNLKPFIYYDWEKTILKNTKENYSINEIIPKTFFMELHGTKITNSTLNGTWKSWNLTNEGEGSYPVLKCIIDDGYLDMNFGASSEKIPLKNVWIKLCMKINPNSDGTYSIPEKSSSFYIKDNSLKISKDNLILDKYLNKLMLSYFKNNIKNIEMFINKSRIQTKVVGDLSLLGWNTENSVSFRTMNEFIKKDNLYPKDFKAVYSYRKMTFTATGTFDSWEMTTGADGRNIRFKCPIKYAVYDLDGDVFNSSTENFLLIQVDLTYFDSKTTINDPTGENDGKQFNLKIKTNDDKLKNVLIVTYNLTDTDGSMSSEDKDFLSLAFRNWFNENIQQFEQIFAYILLDETAKIPEYQWLKPTQISYGSASVETANDEPDLDASIFSAMSMVENNTNSTPSHAVDNRMLQLTKTQAAFGISFPLFIEHFLKQALLSSQFISVDDIVADINTLTITNNKQIIFGKVENSDGKNVDSSLKPGKLKLSLQNNLIVLELFDLTWEQGRGVTGHFDFRQEYELALESKSGKQIPILKVHDEPEIEYYVEEAQWKTNEDMIVSAVVGTVFSMILGASMKLAGSALSKAGKLIRSKATTIKGRKKIYINRSNVRQLRKDSGATEIELERINRRNSSIAAEDARLISNNGTTSIQTLGDMKKKPMSTGQRIAIGAKKIAGTAVMFGAVGLGMNFGEMLINYINAMENNDYSAIPGINSFMQQCIGAMQWPDKDSELKVTFGKLQGIYLLGGTLEKNNKTDNK
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Reference