2025-01-18_00000041|hard|8WFD

The cryo-EM structure of TdpAB in complex with AMPPNP and DNA; Electron microscopy 2.67Å
Protein #1 586 residues (99% resolved)

MAESPIGVVVSSRRNGPWAELTLVLTPQELDQGKRLLLGELVRVSSGGKDYVGMVLDGYYEPVGRSDPTYTLALAHINQVDLEKEDPWARKEVNFYHHRIVLLGRVVQGGLFAPSTRLLPPVVEARVYRMTEEELQRLLAAEVRTSGSVKAEGKRRYAFGHLAYGLEEGGEYPEVVKEVDPALFVGRRTANFGKTGFGKSNENKVILTLLAHAFPRVGMLILDQNAEYLLQTEATTSPGLAQAFKALGIRGRIRFYTAREEAWARRLKEHLGTEWREYVEVLPLKVDFYHFPELAVALAYQRRRLQGAEPPQYLENAFYNLEDWKHIPDRMAYVYGALRKAGLTPRKGLKIKYKNENYDISEEKSWGNLQEAMENNSQRGDNKGGARELYSRAKVFSFLRAFHAPGKEANFLETIKEDLLGEKTEGEGKVVILDLPSLGEAADFFTLRLMDLLFDRAVELYGKRQANFLVVLEEAHNFLEDKAGIFYRVAKEGRKYGIGMLYSTQSPASIPMEILSQTENFLVKHLSSEEDVKVLKRAKAPFAFVADFLLSEPIIGYSYVYFEPYQPFVVPLRVKLLEHVLKSLDS

MAESPIGVVVSSRRNGPWAELTLVLTPQELDQGKRLLLGELVRVSSGGKDYVGMVLDGYYEPVGRSDPTYTLALAHINQVDLEKEDPWARKEVNFYHHRIVLLGRVVQGGLFAPSTRLLPPVVEARVYRMTEEELQRLLAAEVRTSGSVKAEGKRRYAFGHLAYGLEEGGEYPEVVKEVDPALFVGRRTANFGKTGFGKSNENKVILTLLAHAFPRVGMLILDQNAEYLLQTEATTSPGLAQAFKALGIRGRIRFYTAREEAWARRLKEHLGTEWREYVEVLPLKVDFYHFPELAVALAYQRRRLQGAEPPQYLENAFYNLEDWKHIPDRMAYVYGALRKAGLTPRKGLKIKYKNENYDISEEKSWGNLQEAMENNSQRGDNKGGARELYSRAKVFSFLRAFHAPGKEANFLETIKEDLLGEKTEGEGKVVILDLPSLGEAADFFTLRLMDLLFDRAVELYGKRQANFLVVLEEAHNFLEDKAGIFYRVAKEGRKYGIGMLYSTQSPASIPMEILSQTENFLVKHLSSEEDVKVLKRAKAPFAFVADFLLSEPIIGYSYVYFEPYQPFVVPLRVKLLEHVLKSLDS
Protein #2 375 residues (95% resolved)

MPYAGEGSNPLGLKDFLDDLRLDHYQDLLRELDELYQKLKQERQVPLHGDGEAYPLLTLTVDGGEGRAFEELPLLSFGLVRVAAVGVKGFRLPSIAHLLPGYEVLRDPKGYLEGLLERSEESPAADALKTFFRATGISLEDLGEYYTKDLRAFMGIFRDVLEWAYLVWGVEKVLQESYKDYLFIKDGRLAQLGVRESFRSKLQNYFARKHLLLAGVTKRSRLLAEGLTSLVMARLFAEARGTFVLQVPQELMEKAYRYERQWNADLEGAFVMGRRYVARLLEDTFRPQEGVAIFDLPPYLGEEDAVKVARSLRAHRSVLYGGSVGTVVEAHGRASVARSIPRRMEEEILARFRKAFGEDLAKKLTEWLRLADRED

MPYAGEGSNPLGLKDFLDDLRLDHYQDLLRELDELYQKLKQERQVPLHGDGEAYPLLTLTVDGGEGRAFEELPLLSFGLVRVAAVGVKGFRLPSIAHLLPGYEVLRDPKGYLEGLLERSEESPAADALKTFFRATGISLEDLGEYYTKDLRAFMGIFRDVLEWAYLVWGVEKVLQESYKDYLFIKDGRLAQLGVRESFRSKLQNYFARKHLLLAGVTKRSRLLAEGLTSLVMARLFAEARGTFVLQVPQELMEKAYRYERQWNADLEGAFVMGRRYVARLLEDTFRPQEGVAIFDLPPYLGEEDAVKVARSLRAHRSVLYGGSVGTVVEAHGRASVARSIPRRMEEEILARFRKAFGEDLAKKLTEWLRLADRED
DNA #3 12 bases

(DG)(DC)(DC)(DC)(DT)(DT)(DT)(DT)(DG)(DC)(DA)(DA)

GCCCTTTTGCAA
DNA #4 12 bases

(DT)(DT)(DG)(DC)(DA)(DA)(DA)(DA)(DG)(DG)(DG)(DC)

TTGCAAAAGGGC
Non polymer #5 ANP

InChI=1S/C10H17N6O12P3/c11-8-5-9(13-2-12-8)16(3-14-5)10-7(18)6(17)4(27-10)1-26-31(24,25)28-30(22,23)15-29(19,20)21/h2-4,6-7,10,17-18H,1H2,(H,24,25)(H2,11,12,13)(H4,15,19,20,21,22,23)/t4-,6-,7-,10-/m1/s1

c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)O[P@@](=O)(NP(=O)(O)O)O)O)O)N
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Reference