2025-01-11_00000146
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ligand
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8XRR
A complex structure of PDGFRA with an inhibitor RH140;
X-ray diffraction 2.57Å
Protein #1
356 residues (83% resolved)
Raw Sequence ...
GAMDKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSSKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIIIEYCFYGDLVNYLHKNRDSFLSHKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLKSD
Canonical Sequence ...
GAMDKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSSKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIIIEYCFYGDLVNYLHKNRDSFLSHKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKIHLDFLKSD
Non polymer #2
A1LV8
InChI=1S/C24H25N5O/c1-3-17-5-8-23-27-24(17)21(4-1)28-12-9-18(10-13-28)25-11-2-14-30-19-6-7-20-22(15-19)29(23)16-26-20/h1,3-8,15-16,18,25H,2,9-14H2
InChI=1S/C24H25N5O/c1-3-17-5-8-23-27-24(17)21(4-1)28-12-9-18(10-13-28)25-11-2-14-30-19-6-7-20-22(15-19)29(23)16-26-20/h1,3-8,15-16,18,25H,2,9-14H2
SMILES: c1cc2ccc-3nc2c(c1)N4CCC(CC4)NCCCOc5ccc6c(c5)n3cn6
c1cc2ccc-3nc2c(c1)N4CCC(CC4)NCCCOc5ccc6c(c5)n3cn6
Biounit #1
monomer
Download coordinates
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Model
Reference
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