2025-01-11_00000131|ligand|8XQ2

Crystal structure of spleen tyrosine kinase(SYK)in complex with SKI-G-1693; X-ray diffraction 1.80Å
Protein #1 290 residues (91% resolved)

EEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVNLEHHHHHHHH

EEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVNLEHHHHHHHH
Non polymer #2 A1LV7

InChI=1S/C28H32FN7O3/c1-17-19(12-34-15-24(37)25(16-34)39-2)13-36(33-17)26-7-9-30-28(32-26)31-20-5-6-23-21(11-20)22(14-35(23)10-8-29)27(38)18-3-4-18/h5-7,9,11,13-14,18,24-25,37H,3-4,8,10,12,15-16H2,1-2H3,(H,30,31,32)/t24-,25+/m0/s1

Cc1c(cn(n1)c2ccnc(n2)Nc3ccc4c(c3)c(cn4CCF)C(=O)C5CC5)CN6C[C@@H]([C@@H](C6)OC)O
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Reference