2025-01-11_00000129|ligand|8XQ0

Crystal structure of spleen tyrosine kinase(SYK)in complex with SKI-G-1653; X-ray diffraction 1.95Å
Protein #1 290 residues (91% resolved)

EEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVNLEHHHHHHHH

EEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVNLEHHHHHHHH
Non polymer #2 A1LV4

InChI=1S/C27H31N7O3/c1-16-18(11-33-14-23(35)24(15-33)37-3)12-34(31-16)25-8-9-28-27(30-25)29-19-6-7-22-20(10-19)21(13-32(22)2)26(36)17-4-5-17/h6-10,12-13,17,23-24,35H,4-5,11,14-15H2,1-3H3,(H,28,29,30)/t23-,24-/m0/s1

Cc1c(cn(n1)c2ccnc(n2)Nc3ccc4c(c3)c(cn4C)C(=O)C5CC5)CN6C[C@@H]([C@H](C6)OC)O
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Reference