2024-12-28_00000139|hard|9C6R

Blood cell-specific tubulin in complex with Cryptophycin-52; Electron microscopy 3.20Å
Protein #1 451 residues (97% resolved)

MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSVEGEGEEEGEEY

MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSVEGEGEEEGEEY
Protein #2 446 residues (96% resolved)

MREIVHLQIGQCGNQIGAKFWEVISDEHGIDIAGNYCGNASLQLERINVYFNEAYSHKYVPRSILVDLEPGTMDSVRSSKIGPLFRPDNFIHGNSGAGNNWAKGHYTEGAELIENVMDVVRNECESCDCLQGFQLIHSLGGGTGSGMGTLLINKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNAILSIHQLIENTDETFCIDNEALYDICFRTLKLTNPTYGDLNHLVSLTMSGVTTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTARGSQQYRALSVPELTQQMFDARNMMAACDPRRGRYLTVACIFRGRMSTREVDEQLLSVQTKNSSYFVEWIPNNVKVAVCDIPPRGLKMAATFIGNNTAIQELFIRVSEQFSAMFRRKAFLHWYTGEGMDEMEFSEAEGNTNDLVSEYQQYQDATADVEEYEEAEASPEKET

MREIVHLQIGQCGNQIGAKFWEVISDEHGIDIAGNYCGNASLQLERINVYFNEAYSHKYVPRSILVDLEPGTMDSVRSSKIGPLFRPDNFIHGNSGAGNNWAKGHYTEGAELIENVMDVVRNECESCDCLQGFQLIHSLGGGTGSGMGTLLINKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNAILSIHQLIENTDETFCIDNEALYDICFRTLKLTNPTYGDLNHLVSLTMSGVTTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTARGSQQYRALSVPELTQQMFDARNMMAACDPRRGRYLTVACIFRGRMSTREVDEQLLSVQTKNSSYFVEWIPNNVKVAVCDIPPRGLKMAATFIGNNTAIQELFIRVSEQFSAMFRRKAFLHWYTGEGMDEMEFSEAEGNTNDLVSEYQQYQDATADVEEYEEAEASPEKET
Non polymer #3 GDP

InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1

c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
Non polymer #4 GTP

InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1

c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)O[P@](=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
Non polymer #5 YGY

InChI=1S/C36H45ClN2O8/c1-21(2)17-29-34(42)45-27(22(3)31-32(47-31)24-11-8-7-9-12-24)13-10-14-30(40)39-26(19-23-15-16-28(44-6)25(37)18-23)33(41)38-20-36(4,5)35(43)46-29/h7-12,14-16,18,21-22,26-27,29,31-32H,13,17,19-20H2,1-6H3,(H,38,41)(H,39,40)/b14-10-/t22-,26-,27-,29-,31+,32+/m0/s1

C[C@@H]([C@@H]1C/C=CC(=O)N[C@H](C(=O)NCC(C(=O)O[C@H](C(=O)O1)CC(C)C)(C)C)Cc2ccc(c(c2)Cl)OC)[C@@H]3[C@H](O3)c4ccccc4
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Reference