2024-12-28_00000062|hard|8XK4

Structure of the Argonaute protein from Kurthia massiliensis in complex with guide DNA and 19-mer target DNA in target-released state; Electron microscopy 2.94Å
Protein #1 737 residues (93% resolved)

MEAYITEMVSRERANELEVYVYVFPRKQSDNNYEGVYHIMRAWQRANDLPLAYNQHTIMAFSPVRHMCGYTPMETQKRHINIDSPFERALLERLIKNSLIFTAERHLHAKRVGHALRLNQVQQIRQVIIYEAIELYVNIIENRISIGFHLTHQFEYVYTLQSMIEQGKTIRPGMRVVHSNGRQHYTYTVENVATYGVTDRCPLLQTSIYQYYVEKGAQHILRTFTRSTRVIHVRTKEQRLSYAATLLKPLCTFETMQPQDVLNVSKCIKLSASKRMKCTYRWIQQLRAQYRHLTFAPNPFTIAQNGYKLDQLSTPKVHFHRDYATVVSGMKTGKLYKGGNIKISVLFDEDFYLKHHITKKDIYQFIAVLQKIAIAQGVNMTISTSTKSITGKFTDDFFHHFTEEVEALQPIFAQTTVLAFITSTHLSNKKTRSYQLLKQYFGGKWDIASQVITEKTIEAFQKILHKHGLKNFYPNDEQHCLRVIDVLKNESFYYTVMNILLGVYVKSGIQPWILANTTHSDCFIGIDVSHENGNSAAGMMNVIGSQGHLIQQAPLNGILAGEKIDDTLLANLLKQMIKAYHTQFQRFPKHITIHRDGFWREHTALVEKIMSHYEITYDIVEIIKKPNRRMAFFNSVDNTFSTRQGTVYQRGNEAFLCATNPQQKVGMAQPIKIHQVTKTLPFSHIIEDVYNLSFLHIHAMNKMRLPATIHYADLSATAYQRGQVMPRSGNQTNLPFV

MEAYITEMVSRERANELEVYVYVFPRKQSDNNYEGVYHIMRAWQRANDLPLAYNQHTIMAFSPVRHMCGYTPMETQKRHINIDSPFERALLERLIKNSLIFTAERHLHAKRVGHALRLNQVQQIRQVIIYEAIELYVNIIENRISIGFHLTHQFEYVYTLQSMIEQGKTIRPGMRVVHSNGRQHYTYTVENVATYGVTDRCPLLQTSIYQYYVEKGAQHILRTFTRSTRVIHVRTKEQRLSYAATLLKPLCTFETMQPQDVLNVSKCIKLSASKRMKCTYRWIQQLRAQYRHLTFAPNPFTIAQNGYKLDQLSTPKVHFHRDYATVVSGMKTGKLYKGGNIKISVLFDEDFYLKHHITKKDIYQFIAVLQKIAIAQGVNMTISTSTKSITGKFTDDFFHHFTEEVEALQPIFAQTTVLAFITSTHLSNKKTRSYQLLKQYFGGKWDIASQVITEKTIEAFQKILHKHGLKNFYPNDEQHCLRVIDVLKNESFYYTVMNILLGVYVKSGIQPWILANTTHSDCFIGIDVSHENGNSAAGMMNVIGSQGHLIQQAPLNGILAGEKIDDTLLANLLKQMIKAYHTQFQRFPKHITIHRDGFWREHTALVEKIMSHYEITYDIVEIIKKPNRRMAFFNSVDNTFSTRQGTVYQRGNEAFLCATNPQQKVGMAQPIKIHQVTKTLPFSHIIEDVYNLSFLHIHAMNKMRLPATIHYADLSATAYQRGQVMPRSGNQTNLPFV
DNA #2 18 bases

(DT)(DG)(DA)(DG)(DG)(DT)(DA)(DG)(DT)(DA)(DG)(DG)(DT)(DT)(DG)(DT)(DA)(DT)

TGAGGTAGTAGGTTGTAT
DNA #3 10 bases

(DT)(DA)(DC)(DT)(DA)(DC)(DC)(DT)(DC)(DA)

TACTACCTCA
Non polymer #4 DC

InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/t5-,6+,8+/m0/s1

C1[C@@H]([C@H](O[C@H]1N2C=CC(=NC2=O)N)COP(=O)(O)O)O
Non polymer #5 MN

InChI=1S/Mn/q+2

[Mn+2]
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Reference