2024-12-14_00000317|hard|8XK0

Structure of the Argonaute protein from Kurthia massiliensis in complex with guide DNA and 19-mer target DNA in pre-cleavage state; Electron microscopy 2.96Å
Protein #1 737 residues (94% resolved)

MEAYITEMVSRERANELEVYVYVFPRKQSDNNYEGVYHIMRAWQRANDLPLAYNQHTIMAFSPVRHMCGYTPMETQKRHINIDSPFERALLERLIKNSLIFTAERHLHAKRVGHALRLNQVQQIRQVIIYEAIELYVNIIENRISIGFHLTHQFEYVYTLQSMIEQGKTIRPGMRVVHSNGRQHYTYTVENVATYGVTDRCPLLQTSIYQYYVEKGAQHILRTFTRSTRVIHVRTKEQRLSYAATLLKPLCTFETMQPQDVLNVSKCIKLSASKRMKCTYRWIQQLRAQYRHLTFAPNPFTIAQNGYKLDQLSTPKVHFHRDYATVVSGMKTGKLYKGGNIKISVLFDEDFYLKHHITKKDIYQFIAVLQKIAIAQGVNMTISTSTKSITGKFTDDFFHHFTEEVEALQPIFAQTTVLAFITSTHLSNKKTRSYQLLKQYFGGKWDIASQVITEKTIEAFQKILHKHGLKNFYPNDEQHCLRVIDVLKNESFYYTVMNILLGVYVKSGIQPWILANTTHSDCFIGIDVSHENGNSAAGMMNVIGSQGHLIQQAPLNGILAGEKIDDTLLANLLKQMIKAYHTQFQRFPKHITIHRDGFWREHTALVEKIMSHYEITYDIVEIIKKPNRRMAFFNSVDNTFSTRQGTVYQRGNEAFLCATNPQQKVGMAQPIKIHQVTKTLPFSHIIEDVYNLSFLHIHAMNKMRLPATIHYADLSATAYQRGQVMPRSGNQTNLPFV

MEAYITEMVSRERANELEVYVYVFPRKQSDNNYEGVYHIMRAWQRANDLPLAYNQHTIMAFSPVRHMCGYTPMETQKRHINIDSPFERALLERLIKNSLIFTAERHLHAKRVGHALRLNQVQQIRQVIIYEAIELYVNIIENRISIGFHLTHQFEYVYTLQSMIEQGKTIRPGMRVVHSNGRQHYTYTVENVATYGVTDRCPLLQTSIYQYYVEKGAQHILRTFTRSTRVIHVRTKEQRLSYAATLLKPLCTFETMQPQDVLNVSKCIKLSASKRMKCTYRWIQQLRAQYRHLTFAPNPFTIAQNGYKLDQLSTPKVHFHRDYATVVSGMKTGKLYKGGNIKISVLFDEDFYLKHHITKKDIYQFIAVLQKIAIAQGVNMTISTSTKSITGKFTDDFFHHFTEEVEALQPIFAQTTVLAFITSTHLSNKKTRSYQLLKQYFGGKWDIASQVITEKTIEAFQKILHKHGLKNFYPNDEQHCLRVIDVLKNESFYYTVMNILLGVYVKSGIQPWILANTTHSDCFIGIDVSHENGNSAAGMMNVIGSQGHLIQQAPLNGILAGEKIDDTLLANLLKQMIKAYHTQFQRFPKHITIHRDGFWREHTALVEKIMSHYEITYDIVEIIKKPNRRMAFFNSVDNTFSTRQGTVYQRGNEAFLCATNPQQKVGMAQPIKIHQVTKTLPFSHIIEDVYNLSFLHIHAMNKMRLPATIHYADLSATAYQRGQVMPRSGNQTNLPFV
DNA #2 18 bases

(DT)(DG)(DA)(DG)(DG)(DT)(DA)(DG)(DT)(DA)(DG)(DG)(DT)(DT)(DG)(DT)(DA)(DT)

TGAGGTAGTAGGTTGTAT
DNA #3 19 bases

(DT)(DA)(DT)(DA)(DC)(DA)(DA)(DC)(DC)(DT)(DA)(DC)(DT)(DA)(DC)(DC)(DT)(DC)(DA)

TATACAACCTACTACCTCA
Non polymer #4 MN

InChI=1S/Mn/q+2

[Mn+2]
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Reference