2024-11-30_00000123|hard|8XPO

Cryo-EM structure of Lassa virus RdRP elongation complex with the NTP form of compound HNC-1664 bound in the active site; Electron microscopy 3.02Å
Protein #1 2231 residues (77% resolved)

MEEDIAYVKDLVSKYLVDNERLSRQKLAFLVQTEPRMLLMEGLKLLSLCIEVDSCNANGCEHNSEDKSVEKILHECGILTPSLCFVVPDGYKLTGNVLILLECFVRSSPANFEQKYIEDLKKLEQLREDLKSVDINLIPLIDGRTSFYNEQLPDWVNDKLRDTLFSLLRYAQESNSLFEESEYSRLCESLSMTSGRLSGIESLNTLLDNRSDHYEEIIALCHQGINNKLTAHEVKLQIEEEYQVFRNRLRGGEIKCQFMRVNKDHLLSEFNKLYIDDGVVVEENLEQLTHQFKRASPILRFLYSDIEGEEDRRNTQAIKEHQMQCWRSFLNKVKSLRILNTRRKLLLIFDTLILLASKYDHIKQGCLQGWLGSCFVSVNDRLVSLDSTKRDLKKWIERRQQVESSKSTAPSQCLSKNQILSSIIQKTIKRATAAMEDVGINMNHFGVDMSVIGLDCYDSIMNFDVTGVTPTISYQKSQEETFPYAMGVVELSETTDLGRLSSLSLALINSMKTSSTVKLRQNEFGAARYQVVRCKEAYCQEFLLDGVKFQLVYQKTGECSKCYAINNDKVGEVCSFYADPKRYFPAIFSAEVLQATVDTMITWIKDCNELEKELTHIKLLTKMILVLILAHPSKRSQKLLQNLRYFIMAYVSDYHHVDLMDKIKEKLITETEFLLYKLIRALISLILCNEVKSMMTNRFKFILNVSYMCHFITKETPDRLTDQIKCFEKFLEPKIEFGHVSVNPADIATEEELMDMAYHAKKFLSKEGCTAPRGPEYKKPGVSKKFLSLLTSSFNNGSLFKEKEVKKELRDPIITSGCATALDLASNKSVVVNKYTDGSRVLNYDFNKLTALAVTQLTEVFSRKGKHLLNRQDYEYKVQQAMSNLVLGSQQQGVNVDRSDLDEILLEGSASLYFDQLRETVQKIVDQYREPAGLGSMKGGNSEPSINDLDELIPNKFHIRLIKGELSNHMVEDFDCEILPDSFYKEFCDNVYSNHKMKEKYFYCGHMSQCPIGELSKAVTTRTYFEQEYFQCFKSVLLIMNANKLMGKYSHYRSRNLNFKFDTGKLSDDVRISERESNSEALSKALSLTNCTTAMLKNLCFYSQESPQSYNSVGPDTGRLKFSLSYKEQVGGNRELYIGDLRTKMFTRLIEDYFEALSLQLSGSCLNNEKEFENAILSMKLNVSLAHVSYSMDHSKWGPMMCPFLFLAVLQNLIFLSKDLQADIKGRDYLSTLLTWHMHKMVEIPFNVVSAMMKSFIKAQLGLRKSTSQSITEDFFYSNFQVGVVPSHVSSILDMGQGILHNTSDFYALISERFINYAISSVCGGSIDAYTSSDDQISLFNQDLTDLMQRDPEEFKTLLEFHYYMSNQLNKFISPKSVVGRFVAEFKSRFYVWGDEVPLLTKFVAAALHNIKCKEPHQLAETIDTIIDQSVANGVPVHLCNLIQLRTLSLLQYARYPIDPFLLNCETDVKDWVDGNRSYRIMRQIESLIPEACGKIRSMLRKLFNKLKTGQLHEEFTTNYLSGEHVSSLKNLCIILDVDPPSESDLEFSWLNLAAYHPLRMVLRQKVIYSGAVNLDDEKIPTIVKTIQNKLSSTFTRGAQKLLSEAINKSAFQSSIASGFVGLCRTLGSKCVRGPNKENLYIKSIQSLISNTQGIELLTNNHGIQYWRVPLNLKEEKISVAGYFRPLLWDYMCISLSTAIELGAWVLGEPKAAKPLEFFKHNPCDYFPLKPTASKLLEDRVGVNHIIHSLRRLYPSMFEKHILPFMSDLASTKMKWSPRIKFLDLCVALDVNCEALSLVSHIVKWKREEHYIVLSSELRLSHSRSHEPMVEERVVSTSDAVDNFMRQIYFESYVRSFVATTRTLGSFTWFPHKTSIPEGEGLQRLGPFSSFVEKVIYKGIERPMFKYDLMMGYAWIDFDVEPAKFNYNQLIASGLVSSKFDSLEDFFDAIESLPPGSVKLSQTIRFQIKSQDASFRESFAIHLNFVGSMNEQGKYLVQDVAVMYSGAVNSCVLTDCWRLVLSGPTFKGKSAWYVDTEAINEFMSDTNQLGEVTPVEIVIDIDRLQFVEHDFVLVGPCSEAIPLVVHRGGLWECNKRLASFSPVLQDQDLELFVREVGDTSPDLLIGALSAMMLDRLKLRMQWSGVDIVSVLKKVMPKDGLKVLNAAFEAVDDWIEFKGYALCFSKSKRRVMIQSSGGKLRLKGRTCEELLEKEEEVEDIESASNSLEVLFQ

MEEDIAYVKDLVSKYLVDNERLSRQKLAFLVQTEPRMLLMEGLKLLSLCIEVDSCNANGCEHNSEDKSVEKILHECGILTPSLCFVVPDGYKLTGNVLILLECFVRSSPANFEQKYIEDLKKLEQLREDLKSVDINLIPLIDGRTSFYNEQLPDWVNDKLRDTLFSLLRYAQESNSLFEESEYSRLCESLSMTSGRLSGIESLNTLLDNRSDHYEEIIALCHQGINNKLTAHEVKLQIEEEYQVFRNRLRGGEIKCQFMRVNKDHLLSEFNKLYIDDGVVVEENLEQLTHQFKRASPILRFLYSDIEGEEDRRNTQAIKEHQMQCWRSFLNKVKSLRILNTRRKLLLIFDTLILLASKYDHIKQGCLQGWLGSCFVSVNDRLVSLDSTKRDLKKWIERRQQVESSKSTAPSQCLSKNQILSSIIQKTIKRATAAMEDVGINMNHFGVDMSVIGLDCYDSIMNFDVTGVTPTISYQKSQEETFPYAMGVVELSETTDLGRLSSLSLALINSMKTSSTVKLRQNEFGAARYQVVRCKEAYCQEFLLDGVKFQLVYQKTGECSKCYAINNDKVGEVCSFYADPKRYFPAIFSAEVLQATVDTMITWIKDCNELEKELTHIKLLTKMILVLILAHPSKRSQKLLQNLRYFIMAYVSDYHHVDLMDKIKEKLITETEFLLYKLIRALISLILCNEVKSMMTNRFKFILNVSYMCHFITKETPDRLTDQIKCFEKFLEPKIEFGHVSVNPADIATEEELMDMAYHAKKFLSKEGCTAPRGPEYKKPGVSKKFLSLLTSSFNNGSLFKEKEVKKELRDPIITSGCATALDLASNKSVVVNKYTDGSRVLNYDFNKLTALAVTQLTEVFSRKGKHLLNRQDYEYKVQQAMSNLVLGSQQQGVNVDRSDLDEILLEGSASLYFDQLRETVQKIVDQYREPAGLGSMKGGNSEPSINDLDELIPNKFHIRLIKGELSNHMVEDFDCEILPDSFYKEFCDNVYSNHKMKEKYFYCGHMSQCPIGELSKAVTTRTYFEQEYFQCFKSVLLIMNANKLMGKYSHYRSRNLNFKFDTGKLSDDVRISERESNSEALSKALSLTNCTTAMLKNLCFYSQESPQSYNSVGPDTGRLKFSLSYKEQVGGNRELYIGDLRTKMFTRLIEDYFEALSLQLSGSCLNNEKEFENAILSMKLNVSLAHVSYSMDHSKWGPMMCPFLFLAVLQNLIFLSKDLQADIKGRDYLSTLLTWHMHKMVEIPFNVVSAMMKSFIKAQLGLRKSTSQSITEDFFYSNFQVGVVPSHVSSILDMGQGILHNTSDFYALISERFINYAISSVCGGSIDAYTSSDDQISLFNQDLTDLMQRDPEEFKTLLEFHYYMSNQLNKFISPKSVVGRFVAEFKSRFYVWGDEVPLLTKFVAAALHNIKCKEPHQLAETIDTIIDQSVANGVPVHLCNLIQLRTLSLLQYARYPIDPFLLNCETDVKDWVDGNRSYRIMRQIESLIPEACGKIRSMLRKLFNKLKTGQLHEEFTTNYLSGEHVSSLKNLCIILDVDPPSESDLEFSWLNLAAYHPLRMVLRQKVIYSGAVNLDDEKIPTIVKTIQNKLSSTFTRGAQKLLSEAINKSAFQSSIASGFVGLCRTLGSKCVRGPNKENLYIKSIQSLISNTQGIELLTNNHGIQYWRVPLNLKEEKISVAGYFRPLLWDYMCISLSTAIELGAWVLGEPKAAKPLEFFKHNPCDYFPLKPTASKLLEDRVGVNHIIHSLRRLYPSMFEKHILPFMSDLASTKMKWSPRIKFLDLCVALDVNCEALSLVSHIVKWKREEHYIVLSSELRLSHSRSHEPMVEERVVSTSDAVDNFMRQIYFESYVRSFVATTRTLGSFTWFPHKTSIPEGEGLQRLGPFSSFVEKVIYKGIERPMFKYDLMMGYAWIDFDVEPAKFNYNQLIASGLVSSKFDSLEDFFDAIESLPPGSVKLSQTIRFQIKSQDASFRESFAIHLNFVGSMNEQGKYLVQDVAVMYSGAVNSCVLTDCWRLVLSGPTFKGKSAWYVDTEAINEFMSDTNQLGEVTPVEIVIDIDRLQFVEHDFVLVGPCSEAIPLVVHRGGLWECNKRLASFSPVLQDQDLELFVREVGDTSPDLLIGALSAMMLDRLKLRMQWSGVDIVSVLKKVMPKDGLKVLNAAFEAVDDWIEFKGYALCFSKSKRRVMIQSSGGKLRLKGRTCEELLEKEEEVEDIESASNSLEVLFQ
RNA #2 14 bases

GCGCACCGGGGAUC

GCGCACCGGGGAUC
RNA #3 32 bases

GGGAGAUGAAAGUCUCCAACUGAAGAGUCCAA

GGGAGAUGAAAGUCUCCAACUGAAGAGUCCAA
RNA #4 9 bases

GGACUCUUC

GGACUCUUC
Non polymer #5 A1LVZ

InChI=1S/C12H16FIN3O12P3/c1-5-8-6(14)2-17(11(8)16-4-15-5)12-9(13)10(18)7(27-12)3-26-31(22,23)29-32(24,25)28-30(19,20)21/h2,4,7,9-10,12,18H,3H2,1H3,(H,22,23)(H,24,25)(H2,19,20,21)/t7-,9+,10-,12-/m1/s1

Cc1c2c(cn(c2ncn1)[C@H]3[C@H]([C@@H]([C@H](O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)F)I
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Reference