2024-11-30_00000069|medium|8S4D

Crystal structure of a peptidergic GPCR in complex with a small synthetic G protein-biased agonist; X-ray diffraction 2.58Å
Protein #1 497 residues (77% resolved)

MKTIIALSYIFCLVFADYKDDDDKFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWAVYTYRDYDWPFGTFFCKLSSYLIFVAMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTNKVQCYMDYSMVATVSSEWAWEVGLGVSSTMVGFVVPLTIMLTCYFFAAQTIADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCIAYVNSCLNPFLYAFFDPRFRQACTSMLLMGQSRLEVLFQGPASAWSHPQFEKGSAGSAAGSASAWSHPQFEKHHHHHHHHHH

MKTIIALSYIFCLVFADYKDDDDKFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWAVYTYRDYDWPFGTFFCKLSSYLIFVAMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTNKVQCYMDYSMVATVSSEWAWEVGLGVSSTMVGFVVPLTIMLTCYFFAAQTIADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCIAYVNSCLNPFLYAFFDPRFRQACTSMLLMGQSRLEVLFQGPASAWSHPQFEKGSAGSAAGSASAWSHPQFEKHHHHHHHHHH
Non polymer #2 1PE

InChI=1S/C10H22O6/c11-1-3-13-5-7-15-9-10-16-8-6-14-4-2-12/h11-12H,1-10H2

C(COCCOCCOCCOCCO)O
Non polymer #3 A1D5N

InChI=1S/C25H33N3O3S/c1-5-19(6-2)28-22-10-9-17(25(31)26-18(12-16(3)4)14-24(29)30)13-21(22)27-23(28)15-20-8-7-11-32-20/h7-11,13,16,18-19H,5-6,12,14-15H2,1-4H3,(H,26,31)(H,29,30)/t18-/m0/s1

CCC(CC)n1c2ccc(cc2nc1Cc3cccs3)C(=O)N[C@@H](CC(C)C)CC(=O)O
Non polymer #4 OLA

InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/b10-9-

CCCCCCCCC=C/CCCCCCCC(=O)O
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Reference