2024-11-23_00000138|medium|8RJ7

The crystal structure of the SARS-CoV-2 receptor binding domain in complex with the neutralizing nanobody 1.29; X-ray diffraction 2.10Å

Protein #1 203 residues (97% resolved)

Raw Sequence ...

GSITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKLVPR

Canonical Sequence ...

Protein #2 126 residues (97% resolved)

Raw Sequence ...

QVQLVESGGGSVQAGGSLRLSCAASGYTINTDAVAWFRQAPGKGDERVAVIYTGSGNTNYADSVKGRFTISQDNAKNTVYLQMNSLKPEDTALYYCASGYYGASGYDFNNWGQGTQVTVSSALVPR

Canonical Sequence ...

QVQLVESGGGSVQAGGSLRLSCAASGYTINTDAVAWFRQAPGKGDERVAVIYTGSGNTNYADSVKGRFTISQDNAKNTVYLQMNSLKPEDTALYYCASGYYGASGYDFNNWGQGTQVTVSSALVPR

Non polymer #3 LYS

InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1

SMILES: C(CC[NH3+])C[C@@H](C(=O)O)N

C(CC[NH3+])C[C@@H](C(=O)O)N

Non polymer #4 NAG

InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6-,7-,8-/m1/s1

SMILES: CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O

CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O

Reference