2024-10-26_00000108|hard|8VGM

CryoEM structure of Nav1.7 in complex with engineered conformationally rigid Fab 7A9.4DS; Electron microscopy 2.60Å
Protein #1 296 residues (92% resolved)

MDYKDDDDKGSLVPRGSHMYLRITNIVESSFFTKFIIYLIVLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTIEIILRIYVHRISFFKDPWSLFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRILRLVTAVPQMRKIVSALISVIPGMLSVIALMTLFFYIFAIMATQLFGERFPEWFGTLGESFYTLFQVMTLESWSMGIVRPLMEVYPYAWVFFIPFIFVVTFVMINLVVAIIVDAMAILNQKEEQHIIDEVQSHEDNINNEIIKLREEIVELKELIKTSLKN

MDYKDDDDKGSLVPRGSHMYLRITNIVESSFFTKFIIYLIVLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTIEIILRIYVHRISFFKDPWSLFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRILRLVTAVPQMRKIVSALISVIPGMLSVIALMTLFFYIFAIMATQLFGERFPEWFGTLGESFYTLFQVMTLESWSMGIVRPLMEVYPYAWVFFIPFIFVVTFVMINLVVAIIVDAMAILNQKEEQHIIDEVQSHEDNINNEIIKLREEIVELKELIKTSLKN
Protein #2 236 residues (95% resolved)

EVQLVESGGGCVKPGGSLKLSCAASGFTFSNYAMSWVRQTPEKRLEWVATISNGGRYTYYPDSVKGRFTISRDNAKNSLYLQMSSLRSEDTAMYYCARHLYRYDVGGALDYWGQGTCVTVSSAKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFCECPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPRGPTIKPHHHHHHP

EVQLVESGGGCVKPGGSLKLSCAASGFTFSNYAMSWVRQTPEKRLEWVATISNGGRYTYYPDSVKGRFTISRDNAKNSLYLQMSSLRSEDTAMYYCARHLYRYDVGGALDYWGQGTCVTVSSAKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFCECPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPRGPTIKPHHHHHHP
Protein #3 215 residues (100% resolved)

EIVLTQSPALMAASPGEKVTITCSVSLSISSSNLFWYQQKCETSPKPWIYGTSKLASGVPVRFSGSGSGTSYSLTISSMECEDAATYYCQQWSSHSFTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTCQDSKDCTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC

EIVLTQSPALMAASPGEKVTITCSVSLSISSSNLFWYQQKCETSPKPWIYGTSKLASGVPVRFSGSGSGTSYSLTISSMECEDAATYYCQQWSSHSFTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTCQDSKDCTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC
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Reference