2024-09-28_00000079|hard|8VDF

Cryo-EM structure of human monoclonal antibody C7 targeting IT4VAR22 CIDRa1.7 (PfEMP1 A); Electron microscopy 3.50Å
Protein #1 1153 residues (9% resolved)

MGSQSSKPSKPSVDTNESYKSARNVLERYAESIKQQAENDASGYEKELKGKLEEASFCGAYCELIGVPKYGSTDPCYLDHRWHTNLLHEKVKDRDPCHNRNQKRFDEGRVYECGSGIIKGNGNNRNGGSCAPPRRRHMCDKNLEALTVANTKNSNDLLGNILVTAKYEGDSIVNSYANSGMFNVCTALARSFADIGDIIRGKDLYLGNGDYKEKVSNNLRAIFNKIYENLNDPNVKAHYQKDAPNYYKLREHWWTVNRDQVWKAITCNAPTGADYFRKGSDGTNVFTSQGQCGHYEGAPPTNLDYVPQFLRWFEEWAEEFCRKKKIKLGNVKKACRDESSKLYCSHNGYDCTQTIRNKDICIRESKCTDCSTKCKLYELWLEKQENEFKKQTKKYDKEINGNNSLQNNKNNGIDKKYHNEFYKNFREKGYTSLDKFLKLLNEGMYCKNQKPEEEDIDFTKNGDKGIFYRSEYCQVCPYCGLDCGGKTCTAKQEIYPDCVYNGAYEPPNGAETTEITVLYSADQEGDISNKLSEFCNDENNKNSQKWQCYYVSSENNGCKMEKKNANHTPEVKITKFHNFFEMWVTYLLTETITWKDKLKTCMNNTKTADCIHECNKNCVCFDKWVKQKEDEWNSIKKLFTKEKKMPKQYYGNINIYFESFFFHVMKKLNKEAKWNKLMDELRNKIELSKGNEGTKDLQDAIELLLEYLKEKSTICKDNNTNEACDPTVDPTKNPCGKNTKAGSDKVISVKQIAQYYKRLAHEQLEERGSRSALKGDASKGTYRRQGNPRKLKKVCRIAKDHSNRNHKDSRGRHLCTSYLEFLQTIDDSHNSSNAKRVNNSFLGDVLLSAKLDAAEIIKRYKDQNNIRENIEQKDEEAMCRAVRYSFADLGDIIRGKDLWDHKDFKKLERDLVKIFGKIKDELKSKLGDKYIGDEAKSPYKQLRSDWWEANRHQVWKAMQCKTTTKPFSLNIKCGDTSITPLVDYIPQRLRWMTEWAEWYCKEQSRLYGELVEKCNTCGSSNGIVTTEDCKKKCMQCKQKCEAYKSFIEKWKKQWDEQEKKYQELYRKATQNGSDGSKVTADKDADVVDFLSKLRNKNDTNNLFESAAAYVHDTGNLDDCNAQNIFCEKNCDGKVNDKYVFRKYPYDHAKACNC

MGSQSSKPSKPSVDTNESYKSARNVLERYAESIKQQAENDASGYEKELKGKLEEASFCGAYCELIGVPKYGSTDPCYLDHRWHTNLLHEKVKDRDPCHNRNQKRFDEGRVYECGSGIIKGNGNNRNGGSCAPPRRRHMCDKNLEALTVANTKNSNDLLGNILVTAKYEGDSIVNSYANSGMFNVCTALARSFADIGDIIRGKDLYLGNGDYKEKVSNNLRAIFNKIYENLNDPNVKAHYQKDAPNYYKLREHWWTVNRDQVWKAITCNAPTGADYFRKGSDGTNVFTSQGQCGHYEGAPPTNLDYVPQFLRWFEEWAEEFCRKKKIKLGNVKKACRDESSKLYCSHNGYDCTQTIRNKDICIRESKCTDCSTKCKLYELWLEKQENEFKKQTKKYDKEINGNNSLQNNKNNGIDKKYHNEFYKNFREKGYTSLDKFLKLLNEGMYCKNQKPEEEDIDFTKNGDKGIFYRSEYCQVCPYCGLDCGGKTCTAKQEIYPDCVYNGAYEPPNGAETTEITVLYSADQEGDISNKLSEFCNDENNKNSQKWQCYYVSSENNGCKMEKKNANHTPEVKITKFHNFFEMWVTYLLTETITWKDKLKTCMNNTKTADCIHECNKNCVCFDKWVKQKEDEWNSIKKLFTKEKKMPKQYYGNINIYFESFFFHVMKKLNKEAKWNKLMDELRNKIELSKGNEGTKDLQDAIELLLEYLKEKSTICKDNNTNEACDPTVDPTKNPCGKNTKAGSDKVISVKQIAQYYKRLAHEQLEERGSRSALKGDASKGTYRRQGNPRKLKKVCRIAKDHSNRNHKDSRGRHLCTSYLEFLQTIDDSHNSSNAKRVNNSFLGDVLLSAKLDAAEIIKRYKDQNNIRENIEQKDEEAMCRAVRYSFADLGDIIRGKDLWDHKDFKKLERDLVKIFGKIKDELKSKLGDKYIGDEAKSPYKQLRSDWWEANRHQVWKAMQCKTTTKPFSLNIKCGDTSITPLVDYIPQRLRWMTEWAEWYCKEQSRLYGELVEKCNTCGSSNGIVTTEDCKKKCMQCKQKCEAYKSFIEKWKKQWDEQEKKYQELYRKATQNGSDGSKVTADKDADVVDFLSKLRNKNDTNNLFESAAAYVHDTGNLDDCNAQNIFCEKNCDGKVNDKYVFRKYPYDHAKACNC
Protein #2 227 residues (55% resolved)

EVQLVESGGGLAQPGGSLRLSCAASGFTFRDHGMTWVRQVSGKGLEWLSYITAGSKMSYYSDSVRGRFTISRDNAKNSLYLQMNGLTDEDSAIYYCVKGGGNCPSDTCYPSGYFGLDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKV

EVQLVESGGGLAQPGGSLRLSCAASGFTFRDHGMTWVRQVSGKGLEWLSYITAGSKMSYYSDSVRGRFTISRDNAKNSLYLQMNGLTDEDSAIYYCVKGGGNCPSDTCYPSGYFGLDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKV
Protein #3 212 residues (47% resolved)

QSELTQPPSMSVSPGQTAMITCSMNKYSYISWYQQRPGQSPALVIYQDTRRPSGIPERFSGSNSENTAILTITGTRDLDEADYFCQGWDSNVKAVLFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS

QSELTQPPSMSVSPGQTAMITCSMNKYSYISWYQQRPGQSPALVIYQDTRRPSGIPERFSGSNSENTAILTITGTRDLDEADYFCQGWDSNVKAVLFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS
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Reference