2024-09-28_00000065|hard|8S5W

Cryo-EM structure of fedratinib-bound human SLC19A3 in inward-open state; Electron microscopy 3.05Å
Protein #1 140 residues (87% resolved)

QVQLVESGGGLVQPGDSLRLSCAASGRTFSINAMAWFRQAPGKEREYVAQISWTGGNTYYAESVKGRFTISRDNAKNTVYLQMISLKPEDTAVYYCAADSGGIRLGASRWNYWGQGTQVTVSSGRASSSSHHHHHHEPEA

QVQLVESGGGLVQPGDSLRLSCAASGRTFSINAMAWFRQAPGKEREYVAQISWTGGNTYYAESVKGRFTISRDNAKNTVYLQMISLKPEDTAVYYCAADSGGIRLGASRWNYWGQGTQVTVSSGRASSSSHHHHHHEPEA
Protein #2 535 residues (71% resolved)

MDCYRTSLSSSWIYPTVILCLFGFFSMMRPSEPFLIPYLSGPDKQLTSAEITNEIFPVWTYSYLVLLLPVFVLTDYVRYKPVIILQGISFIITWLLLLFGQGVKTMQVVEFFYGMVTAAEVAYYAYIYSVVSPEHYQRVSGYCRSVTLAAYTAGSVLAQLLVSLAQMSYFYLNVISLASVSVAFLFSLFLPMPKKSMFFHAKPSREIKKSSSVNPVLEETHEGEAPGCEEQKPTSEILSTSGKLNKGQLNSLKPSNVTVDVFVQWFQDLKECYSSKRLFYWSLWWAFATAGFNQVLNYVQILWDYKAPSQDSSIYNGAVEAIATFGGAVAAFAVGYVKVNWDLLGELALVVFSVVNAGSLFLMHYTANIWACYAGYLIFKSSYMLLITIAVFQIAVNLNVERYALVFGINTFIALVIQTIMTVIVVDQRGLNLPVSIQFLVYGSYFAVIAGIFLMRSMYITYSTKSQKDVQSPAPSENPDVSHPEEESNIIMSTKLLEVLFQGPSSGWSHPQFEKGGGSGGGSGGSAWSHPQFEK

MDCYRTSLSSSWIYPTVILCLFGFFSMMRPSEPFLIPYLSGPDKQLTSAEITNEIFPVWTYSYLVLLLPVFVLTDYVRYKPVIILQGISFIITWLLLLFGQGVKTMQVVEFFYGMVTAAEVAYYAYIYSVVSPEHYQRVSGYCRSVTLAAYTAGSVLAQLLVSLAQMSYFYLNVISLASVSVAFLFSLFLPMPKKSMFFHAKPSREIKKSSSVNPVLEETHEGEAPGCEEQKPTSEILSTSGKLNKGQLNSLKPSNVTVDVFVQWFQDLKECYSSKRLFYWSLWWAFATAGFNQVLNYVQILWDYKAPSQDSSIYNGAVEAIATFGGAVAAFAVGYVKVNWDLLGELALVVFSVVNAGSLFLMHYTANIWACYAGYLIFKSSYMLLITIAVFQIAVNLNVERYALVFGINTFIALVIQTIMTVIVVDQRGLNLPVSIQFLVYGSYFAVIAGIFLMRSMYITYSTKSQKDVQSPAPSENPDVSHPEEESNIIMSTKLLEVLFQGPSSGWSHPQFEKGGGSGGGSGGSAWSHPQFEK
Non polymer #3 2TA

InChI=1S/C27H36N6O3S/c1-20-19-28-26(30-21-10-12-23(13-11-21)36-17-16-33-14-5-6-15-33)31-25(20)29-22-8-7-9-24(18-22)37(34,35)32-27(2,3)4/h7-13,18-19,32H,5-6,14-17H2,1-4H3,(H2,28,29,30,31)

Cc1cnc(nc1Nc2cccc(c2)S(=O)(=O)NC(C)(C)C)Nc3ccc(cc3)OCCN4CCCC4
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Reference