2024-08-31_00000040|hard|8KGF

Structure of AmCas12a with crRNA; Electron microscopy 2.90Å
Protein #1 1365 residues (92% resolved)

MGPKKKRKVAAADYKDDDDKSRLEPGEKPYKCPECGKSFSQSGALTRHQRTHTRMRTMVTFENFTKQYQVSKTLRFELIPQGKTLENMKRDGIISVDRQRNDDYQKAKGILDKLYKYILDSTMETAVIDWEELAIAIEEFRKSKDKKTYEKVQSKVRTALLEHVKKQKVGTEDLFKGMFSSKIITGEVLAAFPEIRLSDEENLILEKFKDFTTYFTGFFENRKNVFTDEALSTSFTYRLVNDNFIKFFDNCTVMKNVVNISPDMAKSLETCVSDLGIFPGVSLEEVFSVSFYNRLLTQTGIDQFNQLLGGISGKEGEYKKQGLNEIINLAMQQSPEVKEVLKNKAHRFTPLFKQILSDRSTMSFIPDAFADDDEVLSAVDAYRKYLLEKNIGDRAFQLISDIEEYSPELMRIGGKYVSVLSQLLFNSWSEIRDGVKAYKESLITGKKTKKELENIDKGIKYGVTLQEIKEALPKKDIYEEVKKYAMSVVKDYHAGLAEPLPEKIETDDERASIKHIMDSMLGLYRFLEYFSHDSIEDTDPVFGECLDTILDDMNETVPLYNKVRNFSTRKVYSTEKFKLNFNNSSLANGWDKNKEQANGAVLLKKAGEYFLGIFNSKNKPKLVSDGGGGTGYEKMIYKQFPDFKKMLPKCTISRKETKAHFQKSDEDFTLLTDKFEKSLVITKKIYDLGTQTVNGKKKFQVDYPRLTGDMEGYRAALKEWIDFGKKFIQAYASTAIYDTSLFRNSSDYPDLPSFYKDVDNICYKLTFECIPDAVINDCIDDGSLYLFKLHNKDFSAGSIGKPNLHTLYWKAIFEEENLSDVVVKLNGQAELFYRPKSLTRPVVHEAGEVIINKTTSTGLPVPDDVYVELSKFVRNGKKGNLTDKAKNWLDKVTVRKTPHAIIKDRRFTVDKFFFHVPITLNYKADSSPYRFNDFVRQYVKDCSDVNIIGIDRGERNLIYAVVIDGKGNIIEQRSFNTVGTYNYQEKLEQKEKERQTARQDWATVTKIKDLKKGYLSAVVHELSKMIVKYKAIVVLENLNVGFKRMRGGIAERSVYQQFEKALIDKLNYLVFKDEEQSGYGGVLNAYQLTDKFESFSKMGQQTGFLFYVPAAYTSKIDPLTGFINPFSWKHVKNREDRRNFLNLFSKLYYDVNTHDFVLAYHHSNKDSKYTIKGNWEIADWDILIQENKEVFGKTGTPYCVGKRIVYMDDSTTGHNRMCAYYPHTELKKLLSEYGIEYTSGQDLLKIIQEFDDDKLVKGLFYIIKAALQMRNSNSETGEDYISSPIEGRPGICFDSRAEADTLPHNADANGAFHIAMKGLLLTERIRNDDKLAISNEEWLNYIQEMRGASLVPRGSHHHHHHHHHH

MGPKKKRKVAAADYKDDDDKSRLEPGEKPYKCPECGKSFSQSGALTRHQRTHTRMRTMVTFENFTKQYQVSKTLRFELIPQGKTLENMKRDGIISVDRQRNDDYQKAKGILDKLYKYILDSTMETAVIDWEELAIAIEEFRKSKDKKTYEKVQSKVRTALLEHVKKQKVGTEDLFKGMFSSKIITGEVLAAFPEIRLSDEENLILEKFKDFTTYFTGFFENRKNVFTDEALSTSFTYRLVNDNFIKFFDNCTVMKNVVNISPDMAKSLETCVSDLGIFPGVSLEEVFSVSFYNRLLTQTGIDQFNQLLGGISGKEGEYKKQGLNEIINLAMQQSPEVKEVLKNKAHRFTPLFKQILSDRSTMSFIPDAFADDDEVLSAVDAYRKYLLEKNIGDRAFQLISDIEEYSPELMRIGGKYVSVLSQLLFNSWSEIRDGVKAYKESLITGKKTKKELENIDKGIKYGVTLQEIKEALPKKDIYEEVKKYAMSVVKDYHAGLAEPLPEKIETDDERASIKHIMDSMLGLYRFLEYFSHDSIEDTDPVFGECLDTILDDMNETVPLYNKVRNFSTRKVYSTEKFKLNFNNSSLANGWDKNKEQANGAVLLKKAGEYFLGIFNSKNKPKLVSDGGGGTGYEKMIYKQFPDFKKMLPKCTISRKETKAHFQKSDEDFTLLTDKFEKSLVITKKIYDLGTQTVNGKKKFQVDYPRLTGDMEGYRAALKEWIDFGKKFIQAYASTAIYDTSLFRNSSDYPDLPSFYKDVDNICYKLTFECIPDAVINDCIDDGSLYLFKLHNKDFSAGSIGKPNLHTLYWKAIFEEENLSDVVVKLNGQAELFYRPKSLTRPVVHEAGEVIINKTTSTGLPVPDDVYVELSKFVRNGKKGNLTDKAKNWLDKVTVRKTPHAIIKDRRFTVDKFFFHVPITLNYKADSSPYRFNDFVRQYVKDCSDVNIIGIDRGERNLIYAVVIDGKGNIIEQRSFNTVGTYNYQEKLEQKEKERQTARQDWATVTKIKDLKKGYLSAVVHELSKMIVKYKAIVVLENLNVGFKRMRGGIAERSVYQQFEKALIDKLNYLVFKDEEQSGYGGVLNAYQLTDKFESFSKMGQQTGFLFYVPAAYTSKIDPLTGFINPFSWKHVKNREDRRNFLNLFSKLYYDVNTHDFVLAYHHSNKDSKYTIKGNWEIADWDILIQENKEVFGKTGTPYCVGKRIVYMDDSTTGHNRMCAYYPHTELKKLLSEYGIEYTSGQDLLKIIQEFDDDKLVKGLFYIIKAALQMRNSNSETGEDYISSPIEGRPGICFDSRAEADTLPHNADANGAFHIAMKGLLLTERIRNDDKLAISNEEWLNYIQEMRGASLVPRGSHHHHHHHHHH
RNA #2 44 bases

UAAUUUCUACUAAGUGUAGAUGACAUAUGGAAAACGAACUAUGU

UAAUUUCUACUAAGUGUAGAUGACAUAUGGAAAACGAACUAUGU
Non polymer #3 MG

InChI=1S/Mg/q+2

[Mg+2]
Download coordinates
Reference