2024-08-10_00000040|ligand|8OFI

Ivabradine bound to HCN4 channel; Electron microscopy 3.60Å
Protein #1 892 residues (51% resolved)

MDKLPPSMRKRLYSLPQQVGAKAWIMDEEEDAEEEGAGGRQDPRRRSIRLRPLPSPSPSPSAAAAAAGGAESRGAALGGAADGEGPARGAAKSSTNGDCRRFRGSLASLGSRGGGGGGGSTGGGSHGHLHDSAEERRLIAEGDASPGEDRTPPGLAAEPERPGAPAPPAASPPQVPSSCGEQRPADAAVKVEGGAAAGDQILPEAEARLGQAGFMQRQFGAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTDIILDPRRIKMKYLKSWFVVDFVSSIPVDYIFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSLNNMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPMGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGKKNSIHKVQHDLSSGVSNYQENAIVQRIVQHDREMAHCARRAQATTPVAPAIWTPLIQAPLQAAAQDLKLISASQPALPQDGAQTLRRASPHSSSGESVAALPPAGGPFPRAPGRPPGAGPGQHVTLTLPRKASSGSLPPPLSLFGPRAAPRLTAAPQREPGAKSEPVRSKLPSNL

MDKLPPSMRKRLYSLPQQVGAKAWIMDEEEDAEEEGAGGRQDPRRRSIRLRPLPSPSPSPSAAAAAAGGAESRGAALGGAADGEGPARGAAKSSTNGDCRRFRGSLASLGSRGGGGGGGSTGGGSHGHLHDSAEERRLIAEGDASPGEDRTPPGLAAEPERPGAPAPPAASPPQVPSSCGEQRPADAAVKVEGGAAAGDQILPEAEARLGQAGFMQRQFGAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTDIILDPRRIKMKYLKSWFVVDFVSSIPVDYIFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSLNNMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPMGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGKKNSIHKVQHDLSSGVSNYQENAIVQRIVQHDREMAHCARRAQATTPVAPAIWTPLIQAPLQAAAQDLKLISASQPALPQDGAQTLRRASPHSSSGESVAALPPAGGPFPRAPGRPPGAGPGQHVTLTLPRKASSGSLPPPLSLFGPRAAPRLTAAPQREPGAKSEPVRSKLPSNL
Non polymer #2 VNZ

InChI=1S/C27H36N2O5/c1-28(17-21-11-20-14-25(33-4)26(34-5)16-22(20)21)8-6-9-29-10-7-18-12-23(31-2)24(32-3)13-19(18)15-27(29)30/h12-14,16,21H,6-11,15,17H2,1-5H3/t21-/m1/s1

CN(CCCN1CCc2cc(c(cc2CC1=O)OC)OC)C[C@H]3Cc4c3cc(c(c4)OC)OC
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Reference