2024-07-20_00000167|medium|8TGV

CryoEM structure of Fab HC84.26-HCV E2 complex; Electron microscopy 3.75Å
Protein #1 291 residues (75% resolved)

METDTLLLWVLLLWVPGSTGDSTHVTGGTASHTTRHFASLFSSGASQRVQLINTNGSWHINRTALNCNDSLHTGFLAALFYTHKFNASGCPERMAHCRPIDEFAQGWGPITYAEGHGSDQRPYCWHYAPRQCGTIPASQVCGPVYCFTPSPVVVGTTDRFGAPTYTWGENETDVLILNNTRPPQGNWFGCTWMNSTGFTKTCGGPPCNIGGVGNNTLTCPTDCFRKHPEATYTKCGSGPWLTPRCLVDYPYRLWHYPCTVNFTIFKVRMYVGGVEHRLNAACNIGHHHHHH

METDTLLLWVLLLWVPGSTGDSTHVTGGTASHTTRHFASLFSSGASQRVQLINTNGSWHINRTALNCNDSLHTGFLAALFYTHKFNASGCPERMAHCRPIDEFAQGWGPITYAEGHGSDQRPYCWHYAPRQCGTIPASQVCGPVYCFTPSPVVVGTTDRFGAPTYTWGENETDVLILNNTRPPQGNWFGCTWMNSTGFTKTCGGPPCNIGGVGNNTLTCPTDCFRKHPEATYTKCGSGPWLTPRCLVDYPYRLWHYPCTVNFTIFKVRMYVGGVEHRLNAACNIGHHHHHH
Protein #2 255 residues (84% resolved)

METDTLLLWVLLLWVPGSTGDQVQPVQSGAEVKKPGSSVKVSCEASGGTHSNYVITWVRQAPGQGLEWMGGFIPDFRTAMYAQGFQGRVTITADESTSLAYMELTNLRSEDTAVYYCARGPLSRGYYDYWGPGTLVTVSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTAGWSHPQFEK

METDTLLLWVLLLWVPGSTGDQVQPVQSGAEVKKPGSSVKVSCEASGGTHSNYVITWVRQAPGQGLEWMGGFIPDFRTAMYAQGFQGRVTITADESTSLAYMELTNLRSEDTAVYYCARGPLSRGYYDYWGPGTLVTVSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTAGWSHPQFEK
Protein #3 234 residues (91% resolved)

METDTLLLWVLLLWVPGSTGDSYVLTQPPSVSVAPGQTASITCSGDKLGDKYVSWYQQRPGQSPVLVLYQDSKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWDSSALVFGGGTKLTVLRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC

METDTLLLWVLLLWVPGSTGDSYVLTQPPSVSVAPGQTASITCSGDKLGDKYVSWYQQRPGQSPVLVLYQDSKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWDSSALVFGGGTKLTVLRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
Non polymer #4 NAG

InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6-,7-,8-/m1/s1

CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O
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