2024-06-22_00000202|hard|8S0M

Crystal structure of the HKU1 receptor binding domain in complex with TMPRSS2 and the nanobody A01; X-ray diffraction 3.55Å

Protein #1 395 residues (86% resolved)

Raw Sequence ...

KFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDAGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRADGGPFEDDDDK

Canonical Sequence ...

Protein #2 136 residues (96% resolved)

Raw Sequence ...

MAQVQLVESGGGLVQPGGSLRLSCVVSGFSLDYYAIGWFRQAPGKEREGVSCIGSSGDKTNYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCAAESALYSDCTEEQNPMLYDYWGQGTQVTVSSHHHHHH

Canonical Sequence ...

MAQVQLVESGGGLVQPGGSLRLSCVVSGFSLDYYAIGWFRQAPGKEREGVSCIGSSGDKTNYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCAAESALYSDCTEEQNPMLYDYWGQGTQVTVSSHHHHHH

Protein #3 366 residues (95% resolved)

Raw Sequence ...

SGFTVKPVATVYRRIPNLPDCDIDNWLNNVSVPSPLNWERRIFSNCNFNLSTLLRLVHVDSFSCNNLDKSKIFGSCFNSITVDKFAIPNRRRDDLQLGSSGFLQSSNYKIDISSSSCQLYYSLPLVNVTINNFNPSSWNRRYGFGSFNLSSYDVVYSDHCFSVNSDFCPCADPSVVNSCAKSKPPSAICPAGTKYRHCDLDTTLYVKNWCRCSCLPDPISTYSPNTCPQKKVVVGIGEHCPGLGINEEKCGTQLNHSSCFCSPDAFLGWSFDSCISNNRCNIFSNFIFNGINSGTTCSNDLLYSNTEISTGVCVNYDLYGITGQGIFKEVSAVYYNNWQNLLYDSNGNIIGFKDFLTNKTYTILPC

Canonical Sequence ...

Non polymer #4 NAG

InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6-,7-,8-/m1/s1

SMILES: CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O

CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O

Non polymer #5 PO4

InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3

SMILES: [O-]P(=O)([O-])[O-]

[O-]P(=O)([O-])[O-]

Biounit #1 hetero-1-1-1-1-mer

Biounit #2 hetero-1-1-1-mer

Reference