2024-06-15_00000128|hard|8RMM

Structure of heteromeric CALHM2/4 channel in complex with synthetic nanobodies SbC2 and SbC4; Electron microscopy 3.26Å
Protein #1 322 residues (82% resolved)

MSCPTLNNIVSSLQRNGIFINSLIAALTIGGQQLFSSSTFSCPCQVGKNFYYGSAFLVIPALILLVAGFALRSQMWTITGEYCCSCAPPYRRISPLECKLACLRFFSITGRAVIAPLTWLAVTLLTGTYYECAASEFASVDHYPMFDNVSASKREEILAGFPCCRSAPSDVILVRDEIALLHRYQSQMLGWILITLATIAALVSCCVAKCCSPLTSLQHCYWTSHLQNERELFEQAAEQHSRLLMMHRIKKLFGFIPGSEDVKHIRIPSCQDWKDISVPTLLCMGDDLQGHYSFLGNRVDEDNEEDRSRGIELKPALEVLFQ

MSCPTLNNIVSSLQRNGIFINSLIAALTIGGQQLFSSSTFSCPCQVGKNFYYGSAFLVIPALILLVAGFALRSQMWTITGEYCCSCAPPYRRISPLECKLACLRFFSITGRAVIAPLTWLAVTLLTGTYYECAASEFASVDHYPMFDNVSASKREEILAGFPCCRSAPSDVILVRDEIALLHRYQSQMLGWILITLATIAALVSCCVAKCCSPLTSLQHCYWTSHLQNERELFEQAAEQHSRLLMMHRIKKLFGFIPGSEDVKHIRIPSCQDWKDISVPTLLCMGDDLQGHYSFLGNRVDEDNEEDRSRGIELKPALEVLFQ
Protein #2 119 residues (79% resolved)

QGPSQVQLVESGGGLVQAGGSLRLSCAASGFPVYYTHMRWYRQAPGKEREWVAAIYSKGAGTHYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCFVGVGNSYIGQGTQVTVSA

QGPSQVQLVESGGGLVQAGGSLRLSCAASGFPVYYTHMRWYRQAPGKEREWVAAIYSKGAGTHYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCFVGVGNSYIGQGTQVTVSA
Protein #3 331 residues (88% resolved)

MSAALIAENFRFLSLFFKSKDVMIFNGLVALGTVGSQELFSVVAFHCPCSPARNYLYGLAAIGVPALVLFIIGIILNNHTWNLVAECQHRRTKNCSAAPTFLLLSSILGRAAVAPVTWSVISLLRGEAYVCALSEFVDPSSLTAREEHFPSAHATEILARFPCKENPDNLSDFREEVSRRLRYESQLFGWLLIGVVAILVFLTKCLKHYCSPLSYRQEAYWAQYRANEDQLFQRTAEVHSRVLAANNVRRFFGFVALNKDDEELIANFPVEGTQPRPQWNAITGVYLYRENQGLPLYSRLHKWAQGLAGNGAAPDNVEMALLPSALEVLFQ

MSAALIAENFRFLSLFFKSKDVMIFNGLVALGTVGSQELFSVVAFHCPCSPARNYLYGLAAIGVPALVLFIIGIILNNHTWNLVAECQHRRTKNCSAAPTFLLLSSILGRAAVAPVTWSVISLLRGEAYVCALSEFVDPSSLTAREEHFPSAHATEILARFPCKENPDNLSDFREEVSRRLRYESQLFGWLLIGVVAILVFLTKCLKHYCSPLSYRQEAYWAQYRANEDQLFQRTAEVHSRVLAANNVRRFFGFVALNKDDEELIANFPVEGTQPRPQWNAITGVYLYRENQGLPLYSRLHKWAQGLAGNGAAPDNVEMALLPSALEVLFQ
Protein #4 130 residues (96% resolved)

QGPSQVQLVESGGGSVQAGGSLRLSCAASGNIRNISYLGWFRQAPGKEREGVAALWTTQGQTYYADSVKGRFTVSLDNAKNTVYLQMNSLKPEDTALYYCAAATSGQYNPLRGYHYNEYWGQGTQVTVSA

QGPSQVQLVESGGGSVQAGGSLRLSCAASGNIRNISYLGWFRQAPGKEREGVAALWTTQGQTYYADSVKGRFTVSLDNAKNTVYLQMNSLKPEDTALYYCAAATSGQYNPLRGYHYNEYWGQGTQVTVSA
Non polymer #5 PLC

InChI=1S/C32H64NO8P/c1-6-8-10-12-14-16-18-20-22-24-31(34)38-28-30(29-40-42(36,37)39-27-26-33(3,4)5)41-32(35)25-23-21-19-17-15-13-11-9-7-2/h30H,6-29H2,1-5H3/p+1/t30-/m1/s1

CCCCCCCCCCCC(=O)OC[C@H](CO[P@](=O)(O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCC
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Reference