2024-06-15_00000126|hard|8RMK

Cryo-EM structure of human CALHM2 in complex with synthetic nanobody SbC2; Electron microscopy 3.07Å
Protein #1 331 residues (86% resolved)

MSAALIAENFRFLSLFFKSKDVMIFNGLVALGTVGSQELFSVVAFHCPCSPARNYLYGLAAIGVPALVLFIIGIILNNHTWNLVAECQHRRTKNCSAAPTFLLLSSILGRAAVAPVTWSVISLLRGEAYVCALSEFVDPSSLTAREEHFPSAHATEILARFPCKENPDNLSDFREEVSRRLRYESQLFGWLLIGVVAILVFLTKCLKHYCSPLSYRQEAYWAQYRANEDQLFQRTAEVHSRVLAANNVRRFFGFVALNKDDEELIANFPVEGTQPRPQWNAITGVYLYRENQGLPLYSRLHKWAQGLAGNGAAPDNVEMALLPSALEVLFQ

MSAALIAENFRFLSLFFKSKDVMIFNGLVALGTVGSQELFSVVAFHCPCSPARNYLYGLAAIGVPALVLFIIGIILNNHTWNLVAECQHRRTKNCSAAPTFLLLSSILGRAAVAPVTWSVISLLRGEAYVCALSEFVDPSSLTAREEHFPSAHATEILARFPCKENPDNLSDFREEVSRRLRYESQLFGWLLIGVVAILVFLTKCLKHYCSPLSYRQEAYWAQYRANEDQLFQRTAEVHSRVLAANNVRRFFGFVALNKDDEELIANFPVEGTQPRPQWNAITGVYLYRENQGLPLYSRLHKWAQGLAGNGAAPDNVEMALLPSALEVLFQ
Protein #2 154 residues (81% resolved)

SSSQVQLVESGGGSVQAGGSLRLSCAASGNIRNISYLGWFRQAPGKEREGVAALWTTQGQTYYADSVKGRFTVSLDNAKNTVYLQMNSLKPEDTALYYCAAATSGQYNPLRGYHYNEYWGQGTQVTVSAGRAGEQKLISEEDLNSAVDHHHHHH

SSSQVQLVESGGGSVQAGGSLRLSCAASGNIRNISYLGWFRQAPGKEREGVAALWTTQGQTYYADSVKGRFTVSLDNAKNTVYLQMNSLKPEDTALYYCAAATSGQYNPLRGYHYNEYWGQGTQVTVSAGRAGEQKLISEEDLNSAVDHHHHHH
Non polymer #3 PLC

InChI=1S/C32H64NO8P/c1-6-8-10-12-14-16-18-20-22-24-31(34)38-28-30(29-40-42(36,37)39-27-26-33(3,4)5)41-32(35)25-23-21-19-17-15-13-11-9-7-2/h30H,6-29H2,1-5H3/p+1/t30-/m1/s1

CCCCCCCCCCCC(=O)OC[C@H](CO[P@](=O)(O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCC
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Reference