2024-06-08_00000176|medium|8V2E

Crystal structure of B055 scaffold boost immunogen in complex with a mature 10E8 Fab; X-ray diffraction 2.62Å
Protein #1 234 residues (95% resolved)

EVQLVESGGGLVKPGGSLRLSCSASGFDFDNAWMTWVRQPPGKGLEWVGRITGPGEGWSVDYAAPVEGRFTISRLNSINFLYLEMNNLRMEDSGLYFCARTGKYYDFWSGYPPGEEYFQDWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSC

EVQLVESGGGLVKPGGSLRLSCSASGFDFDNAWMTWVRQPPGKGLEWVGRITGPGEGWSVDYAAPVEGRFTISRLNSINFLYLEMNNLRMEDSGLYFCARTGKYYDFWSGYPPGEEYFQDWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSC
Protein #2 215 residues (96% resolved)

SYELTQETGVSVALGRTVTITCRGDSLRSHYASWYQKKPGQAPILLFYGKNNRPSGVPDRFSGSASGNRASLTISGAQAEDDAEYYCSSRDKSGSRLSVFGGGTKLTVLSQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS

SYELTQETGVSVALGRTVTITCRGDSLRSHYASWYQKKPGQAPILLFYGKNNRPSGVPDRFSGSASGNRASLTISGAQAEDDAEYYCSSRDKSGSRLSVFGGGTKLTVLSQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS
Protein #3 188 residues (83% resolved)

ETGNVSQEDIIRALAEPLIDDGMVEKEFADHVIEREKQTPTGLQAEPVGVAIPHTMGEYVRENAISVGILTKPVNFTGWYQSEEPVPVRVVFMLAIRNWFDITNVLNWIKRVIQDRDFMRRLLTMNDEEIYEEIYKKIKQAPNLTGIHFTKKYVRHLNGSGGSGLNDIFEAQKIEWHEGSGGHHHHHH

ETGNVSQEDIIRALAEPLIDDGMVEKEFADHVIEREKQTPTGLQAEPVGVAIPHTMGEYVRENAISVGILTKPVNFTGWYQSEEPVPVRVVFMLAIRNWFDITNVLNWIKRVIQDRDFMRRLLTMNDEEIYEEIYKKIKQAPNLTGIHFTKKYVRHLNGSGGSGLNDIFEAQKIEWHEGSGGHHHHHH
Non polymer #4 NAG

InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6-,7-,8-/m1/s1

CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O
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Reference