2024-06-08_00000089|medium|8R2H

Cryo-EM structure of 1-deoxy-D-xylulose 5-phosphate synthase (DXPS) from Plasmodium falciparum; Electron microscopy 2.42Å
Protein #1 916 residues (77% resolved)

MGSSHHHHHHSSGLVPRGSHMYDIGKYFKQINTFINIDEYKTIYGDEIYKEIYELYVERNIPEYYERKYFSEDIKKSVLFDIDKYNDVEFEKAIKEEFINNGVYINNIDNTYYKKENILIMKKILHYFPLLKLINNPSDLKKLKKQYLPLLAHELKIFLFFIVNITGGHFSSVLSSLEIQLLLLYIFNQPYDNVIYDIGHQAYVHKILTGRKLLFLSLRNKKGISGFLNIFESIYDKFGAGHSSTSLSAIQGYYEAEWQVKNKEKYGNGDIEISDNANVTNNERIFQKGIHNDNNINNNINNNNYINPSDVVGRENTNVPNVRNDNHNVDKVHIAIIGDGGLTGGMALEALNYISFLNSKILIIYNDNGQVSLPTNAVSISGNRPIGSISDHLHYFVSNIEANAGDNKLSKNAKENNIFENLNYDYIGVVNGNNTEELFKVLNNIKENKLKRATVLHVRTKKSNDFINSKSPISILHSIKKNEIFPFDTTILNGNIHKENKIEEEKNVSSSTKYDVNNKNNKNNDNSEIIKYEDMFSKETFTDIYTNEMLKYLKKDRNIIFLSPAMLGGSGLVKISERYPNNVYDVGIAEQHSVTFAAAMAMNKKLKIQLCIYSTFLQRAYDQIIHDLNLQNIPLKVIIGRSGLVGEDGATHQGIYDLSYLGTLNNAYIISPSNQVDLKRALRFAYLDKDHSVYIRIPRMNILSDKYMKGYLNIHMKNESKNIDVNVDINDDVDKYSEEYMDDDNFIKSFIGKSRIIKMDNENNNTNEHYSSRGDTQTKKKKVCIFNMGSMLFNVINAIKEIEKEQYISHNYSFSIVDMIFLNPLDKNMIDHVIKQNKHQYLITYEDNTIGGFSTHFNNYLIENNYITKHNLYVHNIYLSNEPIEHASFKDQQEVVKMDKCSLVNRIKNYLKNNPT

MGSSHHHHHHSSGLVPRGSHMYDIGKYFKQINTFINIDEYKTIYGDEIYKEIYELYVERNIPEYYERKYFSEDIKKSVLFDIDKYNDVEFEKAIKEEFINNGVYINNIDNTYYKKENILIMKKILHYFPLLKLINNPSDLKKLKKQYLPLLAHELKIFLFFIVNITGGHFSSVLSSLEIQLLLLYIFNQPYDNVIYDIGHQAYVHKILTGRKLLFLSLRNKKGISGFLNIFESIYDKFGAGHSSTSLSAIQGYYEAEWQVKNKEKYGNGDIEISDNANVTNNERIFQKGIHNDNNINNNINNNNYINPSDVVGRENTNVPNVRNDNHNVDKVHIAIIGDGGLTGGMALEALNYISFLNSKILIIYNDNGQVSLPTNAVSISGNRPIGSISDHLHYFVSNIEANAGDNKLSKNAKENNIFENLNYDYIGVVNGNNTEELFKVLNNIKENKLKRATVLHVRTKKSNDFINSKSPISILHSIKKNEIFPFDTTILNGNIHKENKIEEEKNVSSSTKYDVNNKNNKNNDNSEIIKYEDMFSKETFTDIYTNEMLKYLKKDRNIIFLSPAMLGGSGLVKISERYPNNVYDVGIAEQHSVTFAAAMAMNKKLKIQLCIYSTFLQRAYDQIIHDLNLQNIPLKVIIGRSGLVGEDGATHQGIYDLSYLGTLNNAYIISPSNQVDLKRALRFAYLDKDHSVYIRIPRMNILSDKYMKGYLNIHMKNESKNIDVNVDINDDVDKYSEEYMDDDNFIKSFIGKSRIIKMDNENNNTNEHYSSRGDTQTKKKKVCIFNMGSMLFNVINAIKEIEKEQYISHNYSFSIVDMIFLNPLDKNMIDHVIKQNKHQYLITYEDNTIGGFSTHFNNYLIENNYITKHNLYVHNIYLSNEPIEHASFKDQQEVVKMDKCSLVNRIKNYLKNNPT
Non polymer #2 MG

InChI=1S/Mg/q+2

[Mg+2]
Non polymer #3 TPP

InChI=1S/C12H18N4O7P2S/c1-8-11(3-4-22-25(20,21)23-24(17,18)19)26-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7H,3-4,6H2,1-2H3,(H4-,13,14,15,17,18,19,20,21)/p+1

Cc1c(sc[n+]1Cc2cnc(nc2N)C)CCO[P@](=O)(O)OP(=O)(O)O
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Reference