2024-06-01_00000175|hard|8WMH

Structure of CbCas9 bound to 6-nucleotide complementary DNA substrate; Electron microscopy 2.60Å
Protein #1 1442 residues (83% resolved)

MIKNILGLALGTNSIGWALVKQDFENKQGEILGMGSRIIPMSQDILGDFGKGNSVSQTAERTKYRSVRRLRERFLLRRERLHRVLYILNFLPEHYASQIDFEKRLGKFKVETEPKLVWKNTDGQFSFLFQNSFNEMLEDFKAAGQELKIPYDWTIYHLRKKAISQKIEKEELAWILLNFNHKRGYYQLRGEDFEEEKDKTFVRLKVDRIVDSGENVKGKILYDVYFENGWKYDKQVVKTEDWVDRTKEFIVSESILKNGETKRTFKAVDSEKDWIAIKTKTEQEIEHSHKTVGTYIYETLLQNPKQKIKGKLVRTIERKFYKEELRQILEKQKEFHQELQSDDLYNDCIRELYRNNEVHQLTLRKKDFVHLFMEDIIFYQRPLRSQKSSVSNCTLEFRKYKGENGAEHTQYLKAIPKSNPYYQEFRLWQWIFNLNLYTKDNDENVTKVFLNTTQDFENLFEFLNTRKEVDQKALLKHFKLNEKTHRWNFVEDKKYPCNETKTMISSRLDKVENISDDFLTRDIEQKIWHIIYSVNDKVEYEKALKSFARKHHLDESSFFEAFRKFPPFKSEYGSFSEKAIKKLLPLMRLGKYWNYAEIDKYSRERIQKIITGEYDENIKDKVREKSVHLTIENDFQGLQLWLAQYIVYGRHSEASMIGKWNSANDLEVFLKDFKQHSLRNPIVEQVITETLRVVKDIWLKYGNGTKDFFNEIHIELGREMKLPADDRKKLTNQITENENTNLRIKALLAEMMNDHSVENVRPFSPMQQEILKIYEDGVLKSDIEIEDDILKISKTAQPSSSDLKRYKLWLEQKYKSPYTGQIIPLNKLFTPEYEIEAIIPQSRYFDDSFSNKIICESAVNKLKDNYIGLGFIKQFGGTIIELGFGKSVKVFDTEEYEDFVKKHYANNRGKRNKLLMEDIPEKMIERQLNDTRYISKYISGILSNIVRVEDGSDEGVNSKNIVPGNGKITTQLKQDWGLNDVWNDLILPRFERMNQLTNSKDFTAWNENHQKFLPTVPIEFSKGFSKKRIDHRHHALDALVIACATTDHVNLLNNQSAKSDTKRYDLKKKLMKFEKVVYHHTQTGEKIEREIPKQFLKPWEKFTVDAKHNLESIIVSFKQNLRVINKATNYYEKYVEKDGTKNKERVEQAGTNWAIRKPMHKDTVSGKVDLPWVKVPKGKILTATRKSLDSSFDLKSIGSITDTGIQKILKNYLAFKDGNPELAFSPEGIDDLNKNIEKYNDGKPHQPINKVRVFELGSKFQVGQTGNKKGKYVEAAKGTNLFFAVYEDEKGKRSYETIPLNEVIERQKQGLTSVPLENEKGSRLLFDLSPNDLVYVPEIDENIDSNFVFSNLNKEKISRIYKVEKTSGTECYFVRQDIAYLIKQYDAKTKIGELESQNKLQVTMTDDRIRITDTCVKINCDRLGNINFITKEKIKQIFNEFR

MIKNILGLALGTNSIGWALVKQDFENKQGEILGMGSRIIPMSQDILGDFGKGNSVSQTAERTKYRSVRRLRERFLLRRERLHRVLYILNFLPEHYASQIDFEKRLGKFKVETEPKLVWKNTDGQFSFLFQNSFNEMLEDFKAAGQELKIPYDWTIYHLRKKAISQKIEKEELAWILLNFNHKRGYYQLRGEDFEEEKDKTFVRLKVDRIVDSGENVKGKILYDVYFENGWKYDKQVVKTEDWVDRTKEFIVSESILKNGETKRTFKAVDSEKDWIAIKTKTEQEIEHSHKTVGTYIYETLLQNPKQKIKGKLVRTIERKFYKEELRQILEKQKEFHQELQSDDLYNDCIRELYRNNEVHQLTLRKKDFVHLFMEDIIFYQRPLRSQKSSVSNCTLEFRKYKGENGAEHTQYLKAIPKSNPYYQEFRLWQWIFNLNLYTKDNDENVTKVFLNTTQDFENLFEFLNTRKEVDQKALLKHFKLNEKTHRWNFVEDKKYPCNETKTMISSRLDKVENISDDFLTRDIEQKIWHIIYSVNDKVEYEKALKSFARKHHLDESSFFEAFRKFPPFKSEYGSFSEKAIKKLLPLMRLGKYWNYAEIDKYSRERIQKIITGEYDENIKDKVREKSVHLTIENDFQGLQLWLAQYIVYGRHSEASMIGKWNSANDLEVFLKDFKQHSLRNPIVEQVITETLRVVKDIWLKYGNGTKDFFNEIHIELGREMKLPADDRKKLTNQITENENTNLRIKALLAEMMNDHSVENVRPFSPMQQEILKIYEDGVLKSDIEIEDDILKISKTAQPSSSDLKRYKLWLEQKYKSPYTGQIIPLNKLFTPEYEIEAIIPQSRYFDDSFSNKIICESAVNKLKDNYIGLGFIKQFGGTIIELGFGKSVKVFDTEEYEDFVKKHYANNRGKRNKLLMEDIPEKMIERQLNDTRYISKYISGILSNIVRVEDGSDEGVNSKNIVPGNGKITTQLKQDWGLNDVWNDLILPRFERMNQLTNSKDFTAWNENHQKFLPTVPIEFSKGFSKKRIDHRHHALDALVIACATTDHVNLLNNQSAKSDTKRYDLKKKLMKFEKVVYHHTQTGEKIEREIPKQFLKPWEKFTVDAKHNLESIIVSFKQNLRVINKATNYYEKYVEKDGTKNKERVEQAGTNWAIRKPMHKDTVSGKVDLPWVKVPKGKILTATRKSLDSSFDLKSIGSITDTGIQKILKNYLAFKDGNPELAFSPEGIDDLNKNIEKYNDGKPHQPINKVRVFELGSKFQVGQTGNKKGKYVEAAKGTNLFFAVYEDEKGKRSYETIPLNEVIERQKQGLTSVPLENEKGSRLLFDLSPNDLVYVPEIDENIDSNFVFSNLNKEKISRIYKVEKTSGTECYFVRQDIAYLIKQYDAKTKIGELESQNKLQVTMTDDRIRITDTCVKINCDRLGNINFITKEKIKQIFNEFR
RNA #2 127 bases

GAGAAUGUCGGGGAGCCGAGGUUGUGAAUUGCUUUCAAAAAUUAUUGAGAAAUAAUUUUGAAAAGCAAUUCACAAUAAGGAUUAUUCCGUUGUGAAAACAUUCAAGGCGGGGCAACUCGCCUUUUUU

GAGAAUGUCGGGGAGCCGAGGUUGUGAAUUGCUUUCAAAAAUUAUUGAGAAAUAAUUUUGAAAAGCAAUUCACAAUAAGGAUUAUUCCGUUGUGAAAACAUUCAAGGCGGGGCAACUCGCCUUUUUU
DNA #3 28 bases

(DC)(DG)(DT)(DT)(DT)(DT)(DG)(DT)(DC)(DT)(DC)(DG)(DG)(DC)(DG)(DA)(DT)(DA)(DA)(DT)(DC)(DA)(DT)(DA)(DG)(DT)(DA)(DG)

CGTTTTGTCTCGGCGATAATCATAGTAG
DNA #4 28 bases

(DC)(DT)(DA)(DC)(DT)(DA)(DT)(DG)(DA)(DT)(DT)(DA)(DT)(DC)(DT)(DA)(DA)(DT)(DC)(DT)(DA)(DC)(DA)(DA)(DA)(DA)(DC)(DG)

CTACTATGATTATCTAATCTACAAAACG
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Reference