2024-05-25_00000185|hard|8QZ4

Crystal structure of human two pore domain potassium ion channel TREK-2 (K2P10.1) in complex with an activatory nanobody (Nb76); X-ray diffraction 3.20Å
Protein #1 282 residues (92% resolved)

MGLQTVMKWKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHVCVSPQELETLIQHALDADNAGVSPIGNSSNNSSHWDLGSAFFFAGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIARVEKVFRKKQVSQTKIRVISTILFILAGCIVFVTIPAVIFKYIEGWTALESIYFVVVTLTTVGFGDFVAGGNAGINYREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLSKKTKEEVGEAENLYFQ

MGLQTVMKWKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHVCVSPQELETLIQHALDADNAGVSPIGNSSNNSSHWDLGSAFFFAGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIARVEKVFRKKQVSQTKIRVISTILFILAGCIVFVTIPAVIFKYIEGWTALESIYFVVVTLTTVGFGDFVAGGNAGINYREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLSKKTKEEVGEAENLYFQ
Protein #2 123 residues (91% resolved)

QVQLVESGGGLVQPGRSLRLSCAASGYIFSSATMAWYRQAPGKQRELVASITRASNTVYADSVKGRFTISRDNGKNTVYLQMNSLKPEDTAVYYCNVWSRGYWGQGTQVTVSSHHHHHHEPEA

QVQLVESGGGLVQPGRSLRLSCAASGYIFSSATMAWYRQAPGKQRELVASITRASNTVYADSVKGRFTISRDNGKNTVYLQMNSLKPEDTAVYYCNVWSRGYWGQGTQVTVSSHHHHHHEPEA
Non polymer #3 BA

InChI=1S/Ba/q+2

[Ba+2]
Non polymer #4 Y01

InChI=1S/C31H50O4/c1-20(2)7-6-8-21(3)25-11-12-26-24-10-9-22-19-23(35-29(34)14-13-28(32)33)15-17-30(22,4)27(24)16-18-31(25,26)5/h9,20-21,23-27H,6-8,10-19H2,1-5H3,(H,32,33)/t21-,23+,24+,25-,26+,27+,30+,31-/m1/s1

CC(C)CCC[C@@H](C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)OC(=O)CCC(=O)O)C)C
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