2024-05-25_00000184|hard|8QZ3

Crystal structure of human two pore domain potassium ion channel TREK-2 (K2P10.1) in complex with an activatory nanobody (Nb67); X-ray diffraction 2.40Å
Protein #1 274 residues (97% resolved)

MKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHVCVSPQELETLIQHALDADNAGVSPIGQSSQQSSHWDLGSAFFFAGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIARVEKVFRKKQVSQTKIRVISTILFILAGCIVFVTIPAVIFKYIEGWTALESIYFVVVTLTTVGFGDFVAGGNAGINYREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLSKKTKEEVGEAENLYFQ

MKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHVCVSPQELETLIQHALDADNAGVSPIGQSSQQSSHWDLGSAFFFAGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIARVEKVFRKKQVSQTKIRVISTILFILAGCIVFVTIPAVIFKYIEGWTALESIYFVVVTLTTVGFGDFVAGGNAGINYREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLSKKTKEEVGEAENLYFQ
Protein #2 137 residues (93% resolved)

QVQLVESGGGLVQAGGSLRLSCAASGRAFSTYVMGWFREAPGKERDFVATLSRGGAVTYYADSVKGRFTISRDNAKNTVYLQMDSLEPEDTAVYYCAARDRLGGAGTATFWGDYDYWGQGTQVTVSSHHHHHHEPEA

QVQLVESGGGLVQAGGSLRLSCAASGRAFSTYVMGWFREAPGKERDFVATLSRGGAVTYYADSVKGRFTISRDNAKNTVYLQMDSLEPEDTAVYYCAARDRLGGAGTATFWGDYDYWGQGTQVTVSSHHHHHHEPEA
Non polymer #3 K

InChI=1S/K/q+1

[K+]
Non polymer #4 MPD

InChI=1S/C6H14O2/c1-5(7)4-6(2,3)8/h5,7-8H,4H2,1-3H3/t5-/m0/s1

C[C@@H](CC(C)(C)O)O
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