2024-05-25_00000183|hard|8QZ2

Crystal structure of human two pore domain potassium ion channel TREK-2 (K2P10.1) in complex with an inhibitory nanobody (Nb61); X-ray diffraction 3.50Å
Protein #1 274 residues (90% resolved)

MKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHVCVSPQELETLIQHALDADNAGVSPIGQSSQQSSHWDLGSAFFFAGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIARVEKVFRKKQVSQTKIRVISTILFILAGCIVFVTIPAVIFKYIEGWTALESIYFVVVTLTTVGFGDFVAGGNAGINYREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLSKKTKEEVGEAENLYFQ

MKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHVCVSPQELETLIQHALDADNAGVSPIGQSSQQSSHWDLGSAFFFAGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIARVEKVFRKKQVSQTKIRVISTILFILAGCIVFVTIPAVIFKYIEGWTALESIYFVVVTLTTVGFGDFVAGGNAGINYREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLSKKTKEEVGEAENLYFQ
Protein #2 134 residues (90% resolved)

QVQLVESGGGLVQAGDSLRVSCAGSGFTFTSYGMGWFRQAPGKEREFVASINWNSNTAYADSVRGRFTISRDNAESMMYLQMNSLKPEDTAVYYCAATRAYSKPRVDSRHYDYWGQGTQVTVSSHHHHHHEPEA

QVQLVESGGGLVQAGDSLRVSCAGSGFTFTSYGMGWFRQAPGKEREFVASINWNSNTAYADSVRGRFTISRDNAESMMYLQMNSLKPEDTAVYYCAATRAYSKPRVDSRHYDYWGQGTQVTVSSHHHHHHEPEA
Non polymer #3 K

InChI=1S/K/q+1

[K+]
Download coordinates
Reference