2024-05-18_00000059|ligand|8P0T

CryoEM structure of 20S Trichomonas vaginalis proteasome in complex with proteasome inhibitor CP-17; Electron microscopy 2.65Å
Protein #1 241 residues (99% resolved)

MSSGADRYLTVFSAEGRLWQVEYSFKAVKQAEVTAVAVKSKNAVCVAVQKKVSDKLIDPSTVTHMYRITDNVGACLVGLPSDVNFIVMLLRSFANNFEYKQGFSIPVSILAQMLSERHQLESQLVYVRPSAVSAILFGLDGPSDSFALYKIEPSGYSNGFRAVACGVKEIEAMSALEKKMEDFETPEATAEFTLSTLQTVCGVDFEAQDVEVSLLTRDNSKFSKLPNDKVNEILHAVAEKD

MSSGADRYLTVFSAEGRLWQVEYSFKAVKQAEVTAVAVKSKNAVCVAVQKKVSDKLIDPSTVTHMYRITDNVGACLVGLPSDVNFIVMLLRSFANNFEYKQGFSIPVSILAQMLSERHQLESQLVYVRPSAVSAILFGLDGPSDSFALYKIEPSGYSNGFRAVACGVKEIEAMSALEKKMEDFETPEATAEFTLSTLQTVCGVDFEAQDVEVSLLTRDNSKFSKLPNDKVNEILHAVAEKD
Protein #2 232 residues (99% resolved)

MGDSDFSLTTFSSGGKLNQIESALKAVSLGGQCVGVKAKNGAVIACESKPSSPLVEKVTNLKVQKINDNVGIVYSGVNTDFHVILKSLRKASIKYSLRLGVEMPTREVVKHAAHKMQYYTQIGGVRPFGVSLLIIGWEELGPTLWQVDPSGTFWAWKATALGKRSDGSRTFLERRYSEDQSVDDAIHTAISTLKEGFDGQLTAELIEIGVVDETRKFRTLSTAEIRDFLTEV

MGDSDFSLTTFSSGGKLNQIESALKAVSLGGQCVGVKAKNGAVIACESKPSSPLVEKVTNLKVQKINDNVGIVYSGVNTDFHVILKSLRKASIKYSLRLGVEMPTREVVKHAAHKMQYYTQIGGVRPFGVSLLIIGWEELGPTLWQVDPSGTFWAWKATALGKRSDGSRTFLERRYSEDQSVDDAIHTAISTLKEGFDGQLTAELIEIGVVDETRKFRTLSTAEIRDFLTEV
Protein #3 251 residues (93% resolved)

MTYRYDAGTTTFSSDGRILQVEYAIQSINQAGTAIGVQFTNGVVLAAEKKNTGRLVDYLFPEKMAKIDGHIVTAVAGLTADANTLVDLMRTSAQKYLKTYDEQMPVEQLVRMVCDEKHSYTQYGGLRPYGVSFLIAGYDRHKGCQLYLTDPSGNFGGWKATAIGENNQTAQSILKSQYKDNMTATEAMDLTVKVLCKTLDSTSLSADKLEFAVLQFREEYGPKVRILTTSEVDTLMKRYEETIKKSAEEKE

MTYRYDAGTTTFSSDGRILQVEYAIQSINQAGTAIGVQFTNGVVLAAEKKNTGRLVDYLFPEKMAKIDGHIVTAVAGLTADANTLVDLMRTSAQKYLKTYDEQMPVEQLVRMVCDEKHSYTQYGGLRPYGVSFLIAGYDRHKGCQLYLTDPSGNFGGWKATAIGENNQTAQSILKSQYKDNMTATEAMDLTVKVLCKTLDSTSLSADKLEFAVLQFREEYGPKVRILTTSEVDTLMKRYEETIKKSAEEKE
Protein #4 235 residues (98% resolved)

MSDYTRSITRFSPDGRLFQIDHAHAAVQRGTTVVATRSKDMIVIAVEKTAVAKLQDPHTFSKICSLDKHVMCAFAGLHADARRLIQSGQRQCQSHRLTYEDPISIENIARYIATLQLKNTQSGGARPYGVSTLICGFDDMTSQPHIYETLPSGTYAEWKARTIGRHDQTVMEYLEKHYKDDMTDEEAQKLAIGALLEVVENGSKNLEVAYMKRGGTMEIMAEEVLDALIESTKAK

MSDYTRSITRFSPDGRLFQIDHAHAAVQRGTTVVATRSKDMIVIAVEKTAVAKLQDPHTFSKICSLDKHVMCAFAGLHADARRLIQSGQRQCQSHRLTYEDPISIENIARYIATLQLKNTQSGGARPYGVSTLICGFDDMTSQPHIYETLPSGTYAEWKARTIGRHDQTVMEYLEKHYKDDMTDEEAQKLAIGALLEVVENGSKNLEVAYMKRGGTMEIMAEEVLDALIESTKAK
Protein #5 251 residues (92% resolved)

MFNSGSEYDRNVNTFSPDGRLLQVEYAIEAVKLGSSAVAILCPEGVIFAVEKRLSSQLLIASSVEKVYAIDDHVGVVMAGLAADGRTMVEHMRVEAQNHRFSFDEPIGIKAVTQSVCDLALAFGEGRRKKGDGQMSRPFGTALLVAGIENGKCHLFHTDPSGTYTECRARAIGGGSEGAEALLRDLYKDGMTLHEAEDLALSTLRQVIQEKLNENNVEVACARVSTGKFEIYTSEQRQEIVARLPPPIIPE

MFNSGSEYDRNVNTFSPDGRLLQVEYAIEAVKLGSSAVAILCPEGVIFAVEKRLSSQLLIASSVEKVYAIDDHVGVVMAGLAADGRTMVEHMRVEAQNHRFSFDEPIGIKAVTQSVCDLALAFGEGRRKKGDGQMSRPFGTALLVAGIENGKCHLFHTDPSGTYTECRARAIGGGSEGAEALLRDLYKDGMTLHEAEDLALSTLRQVIQEKLNENNVEVACARVSTGKFEIYTSEQRQEIVARLPPPIIPE
Protein #6 233 residues (95% resolved)

MFRSKYDENATTFSPEGRILQVENAMKAVQQGMPTVGLKSKTHAVIAGVMHSPSEFSSHQPKIFKIDQHIGVAISGLTADGRGLCKFLRNECLHHTFCFGTEIRVADLADTVALQSQKKTSKVGKRPYGVGLLMIGAGVDGPRLFETCPSGQHWEYNAQAIGRRAQAAKTYLETNLNEFPDCTRDQLIRHALRALNDCKSRESDSLEAIALGVVGIDEPFTILEGPELQKYID

MFRSKYDENATTFSPEGRILQVENAMKAVQQGMPTVGLKSKTHAVIAGVMHSPSEFSSHQPKIFKIDQHIGVAISGLTADGRGLCKFLRNECLHHTFCFGTEIRVADLADTVALQSQKKTSKVGKRPYGVGLLMIGAGVDGPRLFETCPSGQHWEYNAQAIGRRAQAAKTYLETNLNEFPDCTRDQLIRHALRALNDCKSRESDSLEAIALGVVGIDEPFTILEGPELQKYID
Protein #7 240 residues (96% resolved)

MSGAGSGYDFNPITFSPDGRQFQVEYATKAVEKDSLALGVKCKDGILLAAEKNLTSTLLTPGGNPRIFWINDSIACATIGHRPDCYSIVEQSRNRAETFTSNFGIKITVPQLASEVSQQFHLAHYYQAYRPFGCTVIFASYKDDALYAIEPSGAFYGYFASCFGKNSNLARAELQKTEWKNITVREAVPEVARIIKSLHESQFKKWEIEMFWLCEETNGRPQKVPEDVFQSRFVNENPQN

MSGAGSGYDFNPITFSPDGRQFQVEYATKAVEKDSLALGVKCKDGILLAAEKNLTSTLLTPGGNPRIFWINDSIACATIGHRPDCYSIVEQSRNRAETFTSNFGIKITVPQLASEVSQQFHLAHYYQAYRPFGCTVIFASYKDDALYAIEPSGAFYGYFASCFGKNSNLARAELQKTEWKNITVREAVPEVARIIKSLHESQFKKWEIEMFWLCEETNGRPQKVPEDVFQSRFVNENPQN
Protein #8 204 residues (100% resolved)

TTLLAIQCTDGVVMASDSRTSSGSFIPNRATNKITEIQPKIFAARCGNAADTQFLARAVKNYLNALNITRENTDDSTILVASNVIRSLIVRYRQYLSAGVIVGGWDSAGPQVYSIEVSGMAIKKKIASNGSGSTYIQAYIDQNYREDMTMEEATKFAIAAVTGAIIRDGSSGGVVNIVQINADGAKRMTVRPAQQPFNYDIVKG

TTLLAIQCTDGVVMASDSRTSSGSFIPNRATNKITEIQPKIFAARCGNAADTQFLARAVKNYLNALNITRENTDDSTILVASNVIRSLIVRYRQYLSAGVIVGGWDSAGPQVYSIEVSGMAIKKKIASNGSGSTYIQAYIDQNYREDMTMEEATKFAIAAVTGAIIRDGSSGGVVNIVQINADGAKRMTVRPAQQPFNYDIVKG
Protein #9 243 residues (94% resolved)

TIAAAIFDGGVVLGADTRATAGPIVAVKDEMKLHYISDNIWVCGAGIAADNDNINAVISAKLRLFQMNTGLQPRVDQCTNILASRLFQYMGYIQAALIVGGIDFQGPQVYQVAPHGSFSKQPFIAQGSGSLAAISVLENRWHNKMNEHDCMEMVADAIYAGITNDLGSGSHVNLCVIKRENPEDKQSKVIYTFYKDYRVPHENDRNFRLEPQINNIDVEVIKTTERPLTLPDVHLEILDDAPA

TIAAAIFDGGVVLGADTRATAGPIVAVKDEMKLHYISDNIWVCGAGIAADNDNINAVISAKLRLFQMNTGLQPRVDQCTNILASRLFQYMGYIQAALIVGGIDFQGPQVYQVAPHGSFSKQPFIAQGSGSLAAISVLENRWHNKMNEHDCMEMVADAIYAGITNDLGSGSHVNLCVIKRENPEDKQSKVIYTFYKDYRVPHENDRNFRLEPQINNIDVEVIKTTERPLTLPDVHLEILDDAPA
Protein #10 206 residues (99% resolved)

MSDISTYNGSCVLAMAGDHCVAIASDRRLGVNMLTVSKDFKRIFQINDRIYLGLAGLATDVLTVREQLRFDVNLLELREERPIDPKKFMNLVKSTLYEKRFSPFFVTPVIAGLLPETNEPYLAASDSIGAFAFPKDFAVAGTCEESLYGICESAWRPNMNPDELFECTAKCLIAAVERDSISGWGGIVYIITQDKVIIKEIKTRMD

MSDISTYNGSCVLAMAGDHCVAIASDRRLGVNMLTVSKDFKRIFQINDRIYLGLAGLATDVLTVREQLRFDVNLLELREERPIDPKKFMNLVKSTLYEKRFSPFFVTPVIAGLLPETNEPYLAASDSIGAFAFPKDFAVAGTCEESLYGICESAWRPNMNPDELFECTAKCLIAAVERDSISGWGGIVYIITQDKVIIKEIKTRMD
Protein #11 191 residues (100% resolved)

MLSIVGLQGPDWVLIAADSSVSSSIICMSENYDRIAQLDDRHALAMSGETGDCLQLSEYLQGNVALYKFRNGVELSSDALAHFIRHTMAKAVRKSPYEVNMLLSGYDGKPHLYFMDYLGTLQSIPYGAQGYCQYFVMSVFDKHYKEGLTLEDGKELMKLALNQIKQRFTVAPHGFIVKLVDKNGITKIDLE

MLSIVGLQGPDWVLIAADSSVSSSIICMSENYDRIAQLDDRHALAMSGETGDCLQLSEYLQGNVALYKFRNGVELSSDALAHFIRHTMAKAVRKSPYEVNMLLSGYDGKPHLYFMDYLGTLQSIPYGAQGYCQYFVMSVFDKHYKEGLTLEDGKELMKLALNQIKQRFTVAPHGFIVKLVDKNGITKIDLE
Protein #12 202 residues (100% resolved)

TTLSFIYNGGIVVAVDSRATGGQFIFSQTVMKILPLAPNMIGTMAGGAADCQYWLRNLSRLIQLHKFRYQQPLTVAAASKILVNELYRYKGYNLSIGSMICGYDNTGPHIFYIDNHGSRIAGKRFSVGSGSTHAYGVLDTCYREDMTKEEACELGRRAIYHATYRDSGSGGRVSVVHITQNGVEWIDKTDVFDMHDFSKTTF

TTLSFIYNGGIVVAVDSRATGGQFIFSQTVMKILPLAPNMIGTMAGGAADCQYWLRNLSRLIQLHKFRYQQPLTVAAASKILVNELYRYKGYNLSIGSMICGYDNTGPHIFYIDNHGSRIAGKRFSVGSGSTHAYGVLDTCYREDMTKEEACELGRRAIYHATYRDSGSGGRVSVVHITQNGVEWIDKTDVFDMHDFSKTTF
Protein #13 224 residues (95% resolved)

MEGEFRENKKGQWSPYEMHGGTAIGICGDDYVVIGADTRLSVDYSIDSRHKARIFKMNSNCMISATGFDGDIDAFITRMRSILLNYENQHFHEMSVESVARCVSNTLYSKRFFPYYINILVGGINSEGKGKLYGYDPVGTIEDLHYDSNGSGSSLAAPLLDSAFGTIHHNTRPFPAVSLQDAKNIVRDAICSVTERDIYTGDALQLCVFTKDGFAQEEFPLPRH

MEGEFRENKKGQWSPYEMHGGTAIGICGDDYVVIGADTRLSVDYSIDSRHKARIFKMNSNCMISATGFDGDIDAFITRMRSILLNYENQHFHEMSVESVARCVSNTLYSKRFFPYYINILVGGINSEGKGKLYGYDPVGTIEDLHYDSNGSGSSLAAPLLDSAFGTIHHNTRPFPAVSLQDAKNIVRDAICSVTERDIYTGDALQLCVFTKDGFAQEEFPLPRH
Protein #14 244 residues (85% resolved)

MQVITASGAIVAAKYDGGILLASDLSITYGSMFRHNNVSHFVEVAPNIIIGASGEFADFQTLIEVIKSVILQQQCKHNGEYLTASEVHNYIKRYMYQCRSNMKPLSCKVIVAGINPDGSKFLACTDPYGASWESDHIGTGFGKYLQGLQIADVVNGSFDDVKKGITEVFRAVNARNTTANGKIEFITVTPQGINHLAPEQIDPNWEVVEGTWDQSAWSHPQFEKGGGSGGGSGGSAWSHPQFEK

MQVITASGAIVAAKYDGGILLASDLSITYGSMFRHNNVSHFVEVAPNIIIGASGEFADFQTLIEVIKSVILQQQCKHNGEYLTASEVHNYIKRYMYQCRSNMKPLSCKVIVAGINPDGSKFLACTDPYGASWESDHIGTGFGKYLQGLQIADVVNGSFDDVKKGITEVFRAVNARNTTANGKIEFITVTPQGINHLAPEQIDPNWEVVEGTWDQSAWSHPQFEKGGGSGGGSGGSAWSHPQFEK
Non polymer #15 X5C

InChI=1S/C45H56N6O6/c1-5-6-8-21-41(54)48-37(23-31-25-46-35-19-13-11-17-33(31)35)42(55)49-38(24-32-26-47-36-20-14-12-18-34(32)36)43(56)50-40(22-30-15-9-7-10-16-30)45(4)44(3,28-53)51-39(27-52)29(2)57-45/h7,9-20,25-27,29,37-40,46-47,51,53H,5-6,8,21-24,28H2,1-4H3,(H,48,54)(H,49,55)(H,50,56)/t29-,37+,38+,39-,40+,44-,45+/m1/s1

CCCCCC(=O)N[C@@H](Cc1c[nH]c2c1cccc2)C(=O)N[C@@H](Cc3c[nH]c4c3cccc4)C(=O)N[C@@H](Cc5ccccc5)[C@]6([C@@](N[C@@H]([C@H](O6)C)C=O)(C)CO)C
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Reference