2024-04-20_00000148|hard|8KDB

Cryo-EM structure of the human parainfluenza virus hPIV3 L-P polymerase in dimeric form; Electron microscopy 2.70Å
Protein #1 2266 residues (93% resolved)

MISNQQSDNGQKENIKNLGAKRARKMDTESNNGTVSDILYPECHLNSPIVKGKIAQLHTIMSLPQPYDMDDDSILVITRQKIKLNKLDKRQRSIRRLKLILTEKVNDLGKYTFIRYPEMSKEMFKLYIPGINSKVTELLLKADRTYSQMTDGLRDLWINVLSKLASKNDGSNYDLNEEINNISKVHTTYKSDKWYNPFKTWFTIKYDMRRLQKARNEITFNVGKDYNLLEDQKNFLLIHPELVLILDKQNYNGYLITPELVLMYCDVVEGRWNISACAKLDPKLQSMYQKGNNLWEVIDKLFPIMGEKTFDVISLLEPLALSLIQTHDPVKQLRGAFLNHVLSEMELIFESGESIREFLSVDYIDKILDIFNESTIDEIAEIFSFFRTFGHPPLEASIAAEKVRKYMYIEKQLKFDTVNKCHAIFCTIIINGYRERHGGQWPPVTLPDHAHEFIINAYGSNSAISYENAVDYYQSFIGIKFNKFIEPQLDEDLTIYMKDKALSPKKSNWDTVYPASNLLYRTNASNESRRLVEVFIADSKFDPHQILDYVESGDWLDDPEFNISYSLKEKEIKQEGRLFAKMTYKMRATQVLSETLLANNIGKFFQENGMVKGEIELLKRLTTISISGVPRYNEVYNNSKSHTDDLKTYNKISNLNLSSNQKSKKFEFKSTDIYNDGYETVSCFLTTDLKKYCLNWRYESTALFGETCNQIFGLNKLFNWLHPRLEGSTIYVGDPYCPPSDKEHISLEDHPDSGFYVHNPRGGIEGFCQKLWTLISISAIHLAAVRIGVRVTAMVQGDNQAIAVTTRVPNNYDYRIKKEIVYKDVVRFFDSLREVMDDLGHELKLNETIISSKMFIYSKRIYYDGRILPQALKALSRCVFWSETVIDETRSASSNLATSFAKAIENGYSPVLGYACSIFKNIQQLYIALGMNINPTITQNIKDQYFKNSNWMQYASLIPASVGGFNYMAMSRCFVRNIGDPSVAALADIKRFIKANLLDRSVLYRIMNQEPGESSFLDWASDPYSCNLPQSQNITTMIKNITARNVLQDSPNPLLSGLFTNTMIEEDEELAEFLMDRKVILPRVAHDILDNSLTGIRNAIAGMLDTTKSLIRVGINRGGLTYSLLRKISNYDLVQYETLSRTLRLIVSDKIRYEDMCSVDLAIALRQKMWIHLSGGRMISGLETPDPLELLSGVVITGSEHCKICYSSDGTNPYTWMYLPGNIKIGSAETGVSSLRVPYFGSVTDERSEAQLGYIKNLSKPAKAAIRIAMIYTWAFGNDEISWMEASQIAQTRANFTLDSLKILTPVATSTNLSHRLKDTATQMKFSSTSLIRVSRFITMSNDNMSIKEANETKDTNLIYQQIMLTGLSVFEYLFRLKETTGHNPIVMHLHIEDECCIKESFNDEHINPESTLELIRYPESNEFIYDKDPLKDVDLSKLMVIKDHSYTIDMNYWDDTDIIHAISICTAITIADTMSQLDRDNLKEIIVIANDDDINSLITEFLTLDILVFLKTFGGLLVNQFAYTLYSLKIEGRDLIWDYIMRTLRDTSHSILKVLSNALSHPKVFKRFWDCGVLNPIYGPNTASQDQIKLALSICEYALDLFMREWLNGVSLEIYICDSDMEVANDRKQAFISRHLSFVCCLAEIASFGPNLLNLTYLERLDLLKQYLELNIKEDPTLKYVQISGLLIKSFPSTVTYVRKTAIKYLRIRGISPPEVIDDWDPIEDENMLDNIVKTINDNCNKDNKGNKINNFWGLALKNYQVLKIRSITSDSDDNDRLDASTSGLTLPQGGNYLSHQLRLFGINSTSCLKALELSQILMKEVNKDKDRLFLGEGAGAMLACYDATLGPAINYYNSGLNITDVIGQRELKIFPSEVSLVGKKLGNVTQILNRVKVLFNGNPNSTWIGNMECESLIWSELNDKSIGLVHCDMEGAIGKSEETVLHEHYSVIRITYLIGDDDVVLVSKIIPTITPNWSRILYLYKLYWKDVSIISLKTSNPASTELYLISKDAYCTIMEPSEVVLSKLKRLSLLEENNLLKWIILSKKRNNEWLHHEIKEGERDYGVMRPYHMALQIFGFQINLNHLAKEFLSTPDLTNINNIIQSFQRTIKDVLFEWINITHDDKRHKLGGRYNIFPLKNKGKLRLLSRRLVLSWISLSLSTRLLTGRFPDEKFEHRAQTGYVSLADTDLESLKLLSKNIIKNYRECIGSISYWFLTKEVKILMKLIGGAKLLGIPRQYKEPEEQLLENYNQHDEFDIDDYKDDDDK

MISNQQSDNGQKENIKNLGAKRARKMDTESNNGTVSDILYPECHLNSPIVKGKIAQLHTIMSLPQPYDMDDDSILVITRQKIKLNKLDKRQRSIRRLKLILTEKVNDLGKYTFIRYPEMSKEMFKLYIPGINSKVTELLLKADRTYSQMTDGLRDLWINVLSKLASKNDGSNYDLNEEINNISKVHTTYKSDKWYNPFKTWFTIKYDMRRLQKARNEITFNVGKDYNLLEDQKNFLLIHPELVLILDKQNYNGYLITPELVLMYCDVVEGRWNISACAKLDPKLQSMYQKGNNLWEVIDKLFPIMGEKTFDVISLLEPLALSLIQTHDPVKQLRGAFLNHVLSEMELIFESGESIREFLSVDYIDKILDIFNESTIDEIAEIFSFFRTFGHPPLEASIAAEKVRKYMYIEKQLKFDTVNKCHAIFCTIIINGYRERHGGQWPPVTLPDHAHEFIINAYGSNSAISYENAVDYYQSFIGIKFNKFIEPQLDEDLTIYMKDKALSPKKSNWDTVYPASNLLYRTNASNESRRLVEVFIADSKFDPHQILDYVESGDWLDDPEFNISYSLKEKEIKQEGRLFAKMTYKMRATQVLSETLLANNIGKFFQENGMVKGEIELLKRLTTISISGVPRYNEVYNNSKSHTDDLKTYNKISNLNLSSNQKSKKFEFKSTDIYNDGYETVSCFLTTDLKKYCLNWRYESTALFGETCNQIFGLNKLFNWLHPRLEGSTIYVGDPYCPPSDKEHISLEDHPDSGFYVHNPRGGIEGFCQKLWTLISISAIHLAAVRIGVRVTAMVQGDNQAIAVTTRVPNNYDYRIKKEIVYKDVVRFFDSLREVMDDLGHELKLNETIISSKMFIYSKRIYYDGRILPQALKALSRCVFWSETVIDETRSASSNLATSFAKAIENGYSPVLGYACSIFKNIQQLYIALGMNINPTITQNIKDQYFKNSNWMQYASLIPASVGGFNYMAMSRCFVRNIGDPSVAALADIKRFIKANLLDRSVLYRIMNQEPGESSFLDWASDPYSCNLPQSQNITTMIKNITARNVLQDSPNPLLSGLFTNTMIEEDEELAEFLMDRKVILPRVAHDILDNSLTGIRNAIAGMLDTTKSLIRVGINRGGLTYSLLRKISNYDLVQYETLSRTLRLIVSDKIRYEDMCSVDLAIALRQKMWIHLSGGRMISGLETPDPLELLSGVVITGSEHCKICYSSDGTNPYTWMYLPGNIKIGSAETGVSSLRVPYFGSVTDERSEAQLGYIKNLSKPAKAAIRIAMIYTWAFGNDEISWMEASQIAQTRANFTLDSLKILTPVATSTNLSHRLKDTATQMKFSSTSLIRVSRFITMSNDNMSIKEANETKDTNLIYQQIMLTGLSVFEYLFRLKETTGHNPIVMHLHIEDECCIKESFNDEHINPESTLELIRYPESNEFIYDKDPLKDVDLSKLMVIKDHSYTIDMNYWDDTDIIHAISICTAITIADTMSQLDRDNLKEIIVIANDDDINSLITEFLTLDILVFLKTFGGLLVNQFAYTLYSLKIEGRDLIWDYIMRTLRDTSHSILKVLSNALSHPKVFKRFWDCGVLNPIYGPNTASQDQIKLALSICEYALDLFMREWLNGVSLEIYICDSDMEVANDRKQAFISRHLSFVCCLAEIASFGPNLLNLTYLERLDLLKQYLELNIKEDPTLKYVQISGLLIKSFPSTVTYVRKTAIKYLRIRGISPPEVIDDWDPIEDENMLDNIVKTINDNCNKDNKGNKINNFWGLALKNYQVLKIRSITSDSDDNDRLDASTSGLTLPQGGNYLSHQLRLFGINSTSCLKALELSQILMKEVNKDKDRLFLGEGAGAMLACYDATLGPAINYYNSGLNITDVIGQRELKIFPSEVSLVGKKLGNVTQILNRVKVLFNGNPNSTWIGNMECESLIWSELNDKSIGLVHCDMEGAIGKSEETVLHEHYSVIRITYLIGDDDVVLVSKIIPTITPNWSRILYLYKLYWKDVSIISLKTSNPASTELYLISKDAYCTIMEPSEVVLSKLKRLSLLEENNLLKWIILSKKRNNEWLHHEIKEGERDYGVMRPYHMALQIFGFQINLNHLAKEFLSTPDLTNINNIIQSFQRTIKDVLFEWINITHDDKRHKLGGRYNIFPLKNKGKLRLLSRRLVLSWISLSLSTRLLTGRFPDEKFEHRAQTGYVSLADTDLESLKLLSKNIIKNYRECIGSISYWFLTKEVKILMKLIGGAKLLGIPRQYKEPEEQLLENYNQHDEFDIDDYKDDDDK
Protein #2 609 residues (11% resolved)

MESDAKNYQIMDSWEEESRDKSTNISSALNIIEFILSTDPQEDLSENDTINTRTQQLSATIYQPKIKPTETSEKDSGSTDKNRQSGSSHECTTEAKDRTIDQETVQRGPGRRSSSDSRAETVVSGGISRSITNSKNGTQNTEDIDLNEIRKMDKDSIEGKVRQSADVPSEISGSDVIFTTEQSRNSDHGRSLESISTPDTRSISVVTAATPDDEEEILMKNSRTKKSSSIHQEDDKRIKKGGKGKDWFKKSKDTDNQIPTSDYRSTSKGQKKISKTTTINTDTKGQTEIQTESSGTQSSSWNLTIDNNTDRTEQTNTTPPTTTSGSTYTKESIRTNSGSKPKTQKTNGKERKDTEESNRFTERAITLLQNLGVIQSTSKLDLYQDKRVVCVANVLNNVDTASKIDFLAGLVIGVSMDNDTKLTQIQNEMLNLKADLKKMDESHRRLIENQREQLSLITSLISNLKIMTERGGKKDQNESNERVSMIKTKLKEEKIKKTRFDPLMETQGIDKNIPDLYRHAGNTLENDVQVKSEILSSYNESNATRLIPKKVSSTMRSLVAVISNSNLSQSTKQSYINELKHCKNDEEVSELMDMFNEDVNNCQHHHHHH

MESDAKNYQIMDSWEEESRDKSTNISSALNIIEFILSTDPQEDLSENDTINTRTQQLSATIYQPKIKPTETSEKDSGSTDKNRQSGSSHECTTEAKDRTIDQETVQRGPGRRSSSDSRAETVVSGGISRSITNSKNGTQNTEDIDLNEIRKMDKDSIEGKVRQSADVPSEISGSDVIFTTEQSRNSDHGRSLESISTPDTRSISVVTAATPDDEEEILMKNSRTKKSSSIHQEDDKRIKKGGKGKDWFKKSKDTDNQIPTSDYRSTSKGQKKISKTTTINTDTKGQTEIQTESSGTQSSSWNLTIDNNTDRTEQTNTTPPTTTSGSTYTKESIRTNSGSKPKTQKTNGKERKDTEESNRFTERAITLLQNLGVIQSTSKLDLYQDKRVVCVANVLNNVDTASKIDFLAGLVIGVSMDNDTKLTQIQNEMLNLKADLKKMDESHRRLIENQREQLSLITSLISNLKIMTERGGKKDQNESNERVSMIKTKLKEEKIKKTRFDPLMETQGIDKNIPDLYRHAGNTLENDVQVKSEILSSYNESNATRLIPKKVSSTMRSLVAVISNSNLSQSTKQSYINELKHCKNDEEVSELMDMFNEDVNNCQHHHHHH
Non polymer #3 MG

InChI=1S/Mg/q+2

[Mg+2]
Non polymer #4 ZN

InChI=1S/Zn/q+2

[Zn+2]
Download coordinates
Reference