2024-03-30_00000221
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ligand
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8VSG
SARS-CoV-2 main protease with covalent inhibitor;
X-ray diffraction 2.07Å
Protein #1
306 residues (100% resolved)
Raw Sequence ...
SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
Canonical Sequence ...
SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTSEDMLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGVTFQ
Non polymer #2
A1AD0
InChI=1S/C25H33N3O4/c1-24(2)18-13-28(23(32)25(9-10-25)16-6-4-3-5-7-16)20(19(18)24)22(31)27-17(14-29)12-15-8-11-26-21(15)30/h3-7,15,17-20,29H,8-14H2,1-2H3,(H,26,30)(H,27,31)/t15-,17-,18-,19-,20-/m0/s1
InChI=1S/C25H33N3O4/c1-24(2)18-13-28(23(32)25(9-10-25)16-6-4-3-5-7-16)20(19(18)24)22(31)27-17(14-29)12-15-8-11-26-21(15)30/h3-7,15,17-20,29H,8-14H2,1-2H3,(H,26,30)(H,27,31)/t15-,17-,18-,19-,20-/m0/s1
SMILES: CC1([C@@H]2[C@H]1[C@H](N(C2)C(=O)C3(CC3)c4ccccc4)C(=O)N[C@@H](C[C@@H]5CCNC5=O)CO)C
CC1([C@@H]2[C@H]1[C@H](N(C2)C(=O)C3(CC3)c4ccccc4)C(=O)N[C@@H](C[C@@H]5CCNC5=O)CO)C
Non polymer #3
BTB
InChI=1S/C8H19NO5/c10-3-1-9(2-4-11)8(5-12,6-13)7-14/h10-14H,1-7H2
InChI=1S/C8H19NO5/c10-3-1-9(2-4-11)8(5-12,6-13)7-14/h10-14H,1-7H2
SMILES: C(CO)N(CCO)C(CO)(CO)CO
C(CO)N(CCO)C(CO)(CO)CO
Non polymer #4
DMS
InChI=1S/C2H6OS/c1-4(2)3/h1-2H3
InChI=1S/C2H6OS/c1-4(2)3/h1-2H3
SMILES: CS(=O)C
CS(=O)C
Non polymer #5
EDO
InChI=1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2
InChI=1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2
SMILES: C(CO)O
C(CO)O
Biounit #1
homo-dimer
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Model
Reference
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