2024-03-23_00000227
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hard
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8TKP
Structure of the C. elegans TMC-2 complex;
Electron microscopy 2.90Å
Protein #1
1203 residues (51% resolved)
Raw Sequence ...
MPKSGAHQPLVRHDTDDGGETGQSVKSLADVSEEEIDSRMSRRSSVIADLLSLFRRSSSVLVRPHTRLGNPNFDDDDDEFDEEDDKEASKDRILKKIQQKKEIIQKLRGQPWYMKRKRRTLKVAQKHLQQQEAKVSKARLYKAEAGRRLTQASRWLDNLKIYLIPWEAKIRKIESHFGSVVSSYFTFHRWVLGVNITITFIMCMFVVIPEWLADSRTQFGDDRYNKTKAIKVMPPAVRARADELSTVWDFGGYFQYSLLFYGFYSKETFFGETIKYRVPVAYFFCNIFILGFSLFIILRKMAANNRRGTLSSGKTQQYLFNWKAFTGWDYTIGNPETAGNVYMANVIKFREAINDDKQKPSDKHPWIRFVARVLTNLFICAMYVFSIWAIMQCGTLKGEHFFAQNATAITISLITLVFPNIFDLLGKIEKLHPRNALRFQLGRVLVLYILNYYTLIYSLMLQLEHLQKEKNASDNPISALGHPGDAIGRTIRETVLPRYPVDNNPHTYYSYAPVTTTPIPATSSWTTVLPDFGPFGVYNPKASVTKDDTVFSSPVVETHMFGPNSDWNETTVNAASPTGATTRASLRMSQGGLCWETIIGQEITKLVTMDLYMTVASIFLIDFLRGLACRYLNLYWPWDLERTFPEYGEFKVAENVLHLVNNQGMIWLGLFFVPLLPMLNNIKLIILMYIRGWAAMTCNVPASQIFRASRSSNFFFALLILFLFLCTLPVGFVIASKTPSKSCGPFGNQSFFYSVITDVLHENLDKTLVNGIKYSLSPGIIIPVLVLLSLVIYFLIAMVTGLSQANQDLSFQLMVERTEEKKKIFELAGGKKKKSKDNTFGKQKPKQLLPPPTKGVSSDDDSQHNRSTAKSVSGRQFVPSLGSVSEVDHSTGEEQSSDSESTTSSLPPKLSLRQRFLVCIGWADPNKYGRHDDIEMEEGGGRLRELSTGSETDSDDEDSEKSNRDMSYRTAIQSFDQNSQSASASSSKSTTTAPSNSEMRIEITENPLHTYITPLRIEKKSSASSSSSSHQPSSSIEKQAARRLLQPISTTHNIRYGVATVENSSQDPTRPPSTDDSLGDPALHEPLWANLNPHSSYTSAMMSPIMNEVMSNDETTDDEKGRLIPDRPPIPHSPRELKRLKREKDQQSESGSKPSTPRPPRFRISMSPPRKPPSEKNDSDSSNRKYEMRVEKSPKKPKKSDND
Canonical Sequence ...
MPKSGAHQPLVRHDTDDGGETGQSVKSLADVSEEEIDSRMSRRSSVIADLLSLFRRSSSVLVRPHTRLGNPNFDDDDDEFDEEDDKEASKDRILKKIQQKKEIIQKLRGQPWYMKRKRRTLKVAQKHLQQQEAKVSKARLYKAEAGRRLTQASRWLDNLKIYLIPWEAKIRKIESHFGSVVSSYFTFHRWVLGVNITITFIMCMFVVIPEWLADSRTQFGDDRYNKTKAIKVMPPAVRARADELSTVWDFGGYFQYSLLFYGFYSKETFFGETIKYRVPVAYFFCNIFILGFSLFIILRKMAANNRRGTLSSGKTQQYLFNWKAFTGWDYTIGNPETAGNVYMANVIKFREAINDDKQKPSDKHPWIRFVARVLTNLFICAMYVFSIWAIMQCGTLKGEHFFAQNATAITISLITLVFPNIFDLLGKIEKLHPRNALRFQLGRVLVLYILNYYTLIYSLMLQLEHLQKEKNASDNPISALGHPGDAIGRTIRETVLPRYPVDNNPHTYYSYAPVTTTPIPATSSWTTVLPDFGPFGVYNPKASVTKDDTVFSSPVVETHMFGPNSDWNETTVNAASPTGATTRASLRMSQGGLCWETIIGQEITKLVTMDLYMTVASIFLIDFLRGLACRYLNLYWPWDLERTFPEYGEFKVAENVLHLVNNQGMIWLGLFFVPLLPMLNNIKLIILMYIRGWAAMTCNVPASQIFRASRSSNFFFALLILFLFLCTLPVGFVIASKTPSKSCGPFGNQSFFYSVITDVLHENLDKTLVNGIKYSLSPGIIIPVLVLLSLVIYFLIAMVTGLSQANQDLSFQLMVERTEEKKKIFELAGGKKKKSKDNTFGKQKPKQLLPPPTKGVSSDDDSQHNRSTAKSVSGRQFVPSLGSVSEVDHSTGEEQSSDSESTTSSLPPKLSLRQRFLVCIGWADPNKYGRHDDIEMEEGGGRLRELSTGSETDSDDEDSEKSNRDMSYRTAIQSFDQNSQSASASSSKSTTTAPSNSEMRIEITENPLHTYITPLRIEKKSSASSSSSSHQPSSSIEKQAARRLLQPISTTHNIRYGVATVENSSQDPTRPPSTDDSLGDPALHEPLWANLNPHSSYTSAMMSPIMNEVMSNDETTDDEKGRLIPDRPPIPHSPRELKRLKREKDQQSESGSKPSTPRPPRFRISMSPPRKPPSEKNDSDSSNRKYEMRVEKSPKKPKKSDND
Protein #2
201 residues (93% resolved)
Raw Sequence ...
MGNNASSLSELNLFSKGGVFTREQLDEYQDCTFFTRKDIIRLYKRFYALNPHKVPTNMQGNRPAITTLTFEEVEKMPELKENPFKRRICEVFSEDGRGNLSFDDFLDMFSVFSEMAPLQLKLKYAFRIYDYDGDELLGHDDLSKMIRSLTRDELSDVEVEFIIERIIEEADLDGDSSINFAEFEHVVSRSPDFIRTFHIRI
Canonical Sequence ...
MGNNASSLSELNLFSKGGVFTREQLDEYQDCTFFTRKDIIRLYKRFYALNPHKVPTNMQGNRPAITTLTFEEVEKMPELKENPFKRRICEVFSEDGRGNLSFDDFLDMFSVFSEMAPLQLKLKYAFRIYDYDGDELLGHDDLSKMIRSLTRDELSDVEVEFIIERIIEEADLDGDSSINFAEFEHVVSRSPDFIRTFHIRI
Protein #3
117 residues (41% resolved)
Raw Sequence ...
MPSGNEEINHLSALDQFVAPGLRLWMLIALVGGVLLIMIVIVCCFMRIRIPRTKRQIDLIAAKRKLRKSTKNSAEANAHNDERAQAIVMNSMPSGGGGGAPSTSSSRHTGSRIQSQV
Canonical Sequence ...
MPSGNEEINHLSALDQFVAPGLRLWMLIALVGGVLLIMIVIVCCFMRIRIPRTKRQIDLIAAKRKLRKSTKNSAEANAHNDERAQAIVMNSMPSGGGGGAPSTSSSRHTGSRIQSQV
Non polymer #4
CA
InChI=1S/Ca/q+2
InChI=1S/Ca/q+2
SMILES: [Ca+2]
[Ca+2]
Non polymer #5
CLR
InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
SMILES: CC(C)CCC[C@@H](C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C
CC(C)CCC[C@@H](C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C
Non polymer #6
NAG
InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6-,7-,8-/m1/s1
InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6-,7-,8-/m1/s1
SMILES: CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O
CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O
Non polymer #7
PEE
InChI=1S/C41H78NO8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(43)47-37-39(38-49-51(45,46)48-36-35-42)50-41(44)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h17-20,39H,3-16,21-38,42H2,1-2H3,(H,45,46)/b19-17-,20-18-/t39-/m1/s1
InChI=1S/C41H78NO8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(43)47-37-39(38-49-51(45,46)48-36-35-42)50-41(44)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h17-20,39H,3-16,21-38,42H2,1-2H3,(H,45,46)/b19-17-,20-18-/t39-/m1/s1
SMILES: CCCCCCCC/C=CCCCCCCCC(=O)OC[C@H](COP(=O)(O)OCCN)OC(=O)CCCCCCC/C=CCCCCCCCC
CCCCCCCC/C=CCCCCCCCC(=O)OC[C@H](COP(=O)(O)OCCN)OC(=O)CCCCCCC/C=CCCCCCCCC
Non polymer #8
PLM
InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)
InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)
SMILES: CCCCCCCCCCCCCCCC(=O)O
CCCCCCCCCCCCCCCC(=O)O
Non polymer #9
R16
InChI=1S/C16H34/c1-3-5-7-9-11-13-15-16-14-12-10-8-6-4-2/h3-16H2,1-2H3
InChI=1S/C16H34/c1-3-5-7-9-11-13-15-16-14-12-10-8-6-4-2/h3-16H2,1-2H3
SMILES: CCCCCCCCCCCCCCCC
CCCCCCCCCCCCCCCC
Non polymer #10
TWT
InChI=1S/C22H46/c1-3-5-7-9-11-13-15-17-19-21-22-20-18-16-14-12-10-8-6-4-2/h3-22H2,1-2H3
InChI=1S/C22H46/c1-3-5-7-9-11-13-15-17-19-21-22-20-18-16-14-12-10-8-6-4-2/h3-22H2,1-2H3
SMILES: CCCCCCCCCCCCCCCCCCCCCC
CCCCCCCCCCCCCCCCCCCCCC
Biounit #1
hetero-2-2-2-1-1-mer
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Model
Reference
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