2024-03-09_00000157|hard|8SIS

Crystal structure of SARS-CoV-2 spike receptor-binding domain in complex with broadly neutralizing antibody CC84.2 Fab; X-ray diffraction 3.08Å
Protein #1 205 residues (95% resolved)

TNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSGHHHHHH

TNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSGHHHHHH
Protein #2 231 residues (99% resolved)

QVQLVQSGAEVKKPGASVKVSCKASGYTFTRYAMHWVRQAPGQSLECMGWINAGNGNTKYSKNFQGRVTITRDTSANTVYMELSSLRSEDTAVYYCARDLYYYDSSGYQHINYQLDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSC

QVQLVQSGAEVKKPGASVKVSCKASGYTFTRYAMHWVRQAPGQSLECMGWINAGNGNTKYSKNFQGRVTITRDTSANTVYMELSSLRSEDTAVYYCARDLYYYDSSGYQHINYQLDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSC
Protein #3 216 residues (96% resolved)

DVVMTQSPGTLSLSPGERATLSCRASQSVSSNYLAWYQQKAGQAPRLLIYGASSRATDIPDRFSGSGSGTDFTLTISRLEPEDFAMYYCQQYGGSPRTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECS

DVVMTQSPGTLSLSPGERATLSCRASQSVSSNYLAWYQQKAGQAPRLLIYGASSRATDIPDRFSGSGSGTDFTLTISRLEPEDFAMYYCQQYGGSPRTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECS
Non polymer #4 NAG

InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6-,7-,8-/m1/s1

CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O
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Reference