2024-03-02_00000008
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ligand
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8ASF
Crystal structure of Thrombin in complex with macrocycle T1;
X-ray diffraction 2.58Å
Protein #1
36 residues (78% resolved)
Raw Sequence ...
TFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGR
Canonical Sequence ...
TFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGR
Protein #2
259 residues (97% resolved)
Raw Sequence ...
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
Canonical Sequence ...
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
Non polymer #3
NWF
InChI=1S/C29H35ClN4O4S3/c30-25-8-7-24(41-25)27(36)31-12-23-29(38)33-10-1-2-22(15-33)28(37)34-13-21(14-34)18-40-17-20-5-3-19(4-6-20)16-39-11-9-26(35)32-23/h3-8,21-23H,1-2,9-18H2,(H,31,36)(H,32,35)/t22-,23+/m0/s1
InChI=1S/C29H35ClN4O4S3/c30-25-8-7-24(41-25)27(36)31-12-23-29(38)33-10-1-2-22(15-33)28(37)34-13-21(14-34)18-40-17-20-5-3-19(4-6-20)16-39-11-9-26(35)32-23/h3-8,21-23H,1-2,9-18H2,(H,31,36)(H,32,35)/t22-,23+/m0/s1
SMILES: c1cc2ccc1CSCCC(=O)N[C@@H](C(=O)N3CCC[C@@H](C3)C(=O)N4CC(C4)CSC2)CNC(=O)c5ccc(s5)Cl
c1cc2ccc1CSCCC(=O)N[C@@H](C(=O)N3CCC[C@@H](C3)C(=O)N4CC(C4)CSC2)CNC(=O)c5ccc(s5)Cl
Biounit #1
hetero-1-1-mer
Download coordinates
Biounit #2
hetero-1-1-mer
Download coordinates
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Model
Reference
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