2024-02-24_00000053|hard|8GAV

Structure of human NDS.3 Fab in complex with influenza virus neuraminidase from A/Darwin/09/2021 (H3N2); Electron microscopy 2.70Å

Protein #1 467 residues (83% resolved)

Raw Sequence ...

MEFGLSWIFLAAILKGVQCADPHHHHHHHHSSSDRFDVDKLKQEIMTEIRREVSKMKQDIIEAIKVELNRGSLVPRGSGGEYRNWSKPQCGITGFAPFSKDNSIRLSAGGDIWVTREPYVSCDLDKCYQFALGQGTTLNNVHSNNTVSDRTPYRTLLMNELGVPFHLGTKQVCIAWSSSSCHDGKAWLHVCITGDDKNATASFIYNGRLVDSVVSWSNDILRTQESECVCINGTCTVVMTDGNATGKADTKILFIEEGKIVHTSKLSGSAQHVEECSCYPRYPGVRCVCRDNWKGSNRPIIDINIKDHSIVSRYVCSGLVGDTPRKSDSSSSSHCLNPNNEKGDHGVKGWAFDDGNDVWMGRTINETSRLGYETFKVVEGWSNPKSKLQINRQVIVDRGDRSGYSGIFSVEGKSCINRCFYVELIRGRKEETEVLWTSNSIVVFCGTSGTYGTGSWPDGANLSLMHI

Canonical Sequence ...

Protein #2 227 residues (54% resolved)

Raw Sequence ...

EVQLVESGGGLVKPGGSLRLSCAASGFTFSDYSMTWIRQIPGKGLEWLSYTTSSGRPIFYADSVKGRFTMSRDNAKMSVYLQMNSLRDADSAVYYCARGDPHYIWGTYLDSWGPGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDK

Canonical Sequence ...

Protein #3 216 residues (50% resolved)

Raw Sequence ...

QSALTQPPSASGSPGQSVTISCTGTTSDFGDHNYVSWYQQRPGEAPKLIIYDVSKRPSGVPDRFSGSKSGNTASLTVSRLQADDEANYYCSSIEGSNTLLFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS

Canonical Sequence ...

Non polymer #4 NAG

InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6-,7-,8-/m1/s1

SMILES: CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O

CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O

Biounit #1 hetero-4-4-4-mer

Biounit #2 hetero-1-1-1-mer

Biounit #3 hetero-1-1-1-mer

Reference